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DNA Modifications


  • High-efficiency Conversion of 5-mC and 5-hmC DNA for the Truest Downstream Analysis

  • Real-Time PCR Based Detection
  • ELISA-Based Detection
  • Colorimetric Assay Based Detection

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Epigenetics Brochure

Ensure Accuracy in Analysis of DNA Methylation

Convenient Kits for Sample Conversion and Detection

DNA methylation can alter gene expression, cell differentiation and often results in unidirectional changes to genomic DNA. Its involvement in so many cellular processes means errors resulting in abnormal DNA methylation patterns can lead to disease. Expanding our expertise in epigenetic modification analysis, Enzo Life Sciences now offers a portfolio of products that enable detection of DNA methylation.

 

Sample Conversion

High-efficiency Conversion of 5-mC and 5-hmC DNA for the Truest Downstream Analysis

  • Conversion allows for resolution of single nucleotide information
  • Kits provide high conversion rates without the introduction of DNA damage
  • Converted output sample suitable for detection by
    • bisulfite sequencing
    • methylation-specific PCR
    • high resolution melting curve analysis
    • microarray-based approaches
    • next-generation sequencing

 

DNA Methylation Detection

Real-Time PCR Based Detection

BIOPANEL® DNA Methylation Detection Kit for Human Pluripotent Stem Cells

  • No need for bisulfite conversion
  • Determine % methylation of specific region in less than 5 hours
  • Identifies region-specific DNA methylation in RAB25, NANOG, PTPN6, MGMT, GBP3, and LYST gene promoters

ELISA-Based Detection

5-Methylcytosine DNA ELISA kit

  • Accurately quantitate 5-mC in any DNA sample in less than 3 hours
  • Ideal for high-throughput analysis
  • High specificity comparable to LC-MS/MS-MRM analysis
 

Colorimetric Assay Based Detection

DNMT Colorimetric Drug Discovery Kit

Rapid, sensitive, and simple colorimetric DNMT activity/inhibition kit.

 

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For Research Use Only. Not for use in diagnostic procedures.
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