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Sphingolipid metabolism

Sphingolipids are a versatile class of membrane lipid. In addition to providing mechanical stability, sphingolipids plays a role in molecular signaling, sorting and cell recognition. Therefore, a block in sphingolipid synthesis can compromise cell growth and survival. Sphingosine metabolites, such as ceramide, sphingosine, and sphingosine-1- phosphate are lipid signaling molecules which are involved in a diverse cellular processes. Sphingosine metabolites are potent mediators of cellular stress pathways, accumulation in cells can trigger growth arrest and cell death.

Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2, leading to the formation of sphingosine-1-phosphate (S1P). Sphingosine-1-phosphate is a potent signaling lipid involved in numerous biological functions including, cellular proliferation, survival, migration, invasion, differentiation, architecture, immune cell trafficking, angiogenesis and vascular integrity. Due to its diverse function, S1P has been implicated in a broad range of diseases, including atherosclerosis, respiratory distress, diabetes, cancer and inflammatory disorders.

 

Sphingolipid Metabolism Related Products

Sphingosine Kinase 1 Inhibitor (SK1-I)

A sphingosine analog and competitive inhibitor specific for sphingosine kinase 1

Benefits
  • Competitive inhibitor specific for sphingosine kinase 1 (SK1)
  • Exclusive to Enzo Life Sciences
  • High purity ≥ 98% (HPLC)
  • Highly specific (does not inhibit SK2, PKCa, PKCd, PKA, AKT1, ERK1, EGFR, CDK2, IKKb or CamK2b)
  • Decreases sphingosine-1-phosphate levels and increases proapoptotic precursor ceramide
  • SK1-I inhibits tumor cell growth in vitro and in vivo

Highly Specific Inhibitor for SK1

Sphingosine kinase 1 inhibitor


Research Areas
  • Atherosclerosis
  • Cancer
  • Diabetes
  • Hepatitis C
  • Inflammatory disorders
  • Respiratory distress
 

Related Products

 

Activators

C16 Ceramide 

Endogenous ceramide
24696-26-2, ≥98% (TLC) | Print as PDF
 
BML-SL115-0005 5 mg 66.00 USD
 
BML-SL115-0025 25 mg 278.00 USD
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C2 Ceramide 

Cell-permeable ceramide analog
3102-57-6, ≥98% (TLC) | Print as PDF
 
BML-SL100-0005 5 mg 63.00 USD
 
BML-SL100-0025 25 mg 234.00 USD
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C2-Phytoceramide 

Ceramide-activated protein phosphatase activator
475995-69-8, ≥98% (TLC) | Print as PDF
 
BML-SL151-0005 5 mg 264.00 USD
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C6 Ceramide 

Cell-permeable ceramide analog
124753-97-5, ≥98% (TLC) | Print as PDF
 
BML-SL110-0005 5 mg 63.00 USD
 
BML-SL110-0025 25 mg 242.00 USD
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C8 Ceramide 

Ceramide-activated protein kinase activator
74713-59-0, ≥98% (TLC) | Print as PDF
 
BML-SL112-0005 5 mg 61.00 USD
 
BML-SL112-0025 25 mg 242.00 USD
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C8 ceramine, D-erythro 

Ceramide-activated protein kinase activator
170926-06-4, ≥98% (TLC) | Print as PDF
 
BML-SL145-0001 1 mg 72.00 USD
 
BML-SL145-0005 5 mg 295.00 USD
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Sphingosine-1-phosphate, D-erythro 

Endogenous signaling molecule
26993-30-6, Synthetic., ≥98% (TLC) | Print as PDF
 
BML-SL140-0001 1 mg 161.00 USD
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Sphingosylphosphorylcholine 

Induces release of Ca2+ from intracellular stores
82970-80-7, ≥98% (HPLC) | Print as PDF
 
BML-SL141-0010 10 mg 295.00 USD
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Activator/Inducer

Biochemicals

D-erythro-Sphingosine, N-Stearoyl- (synthetic) 

2304-81-6, Synthetic., ≥97% (HPLC) | Print as PDF
 
ALX-306-023-M001 1 mg 16.00 USD
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Inactive Controls

C2 Dihydroceramide 

Negative control for C2 ceramide
13031-64-6, ≥98% (TLC) | Print as PDF
 
BML-SL101-0005 5 mg 69.00 USD
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C6 Dihydroceramide 

Negative control for C6 ceramide
171039-13-7, ≥98% | Print as PDF
 
BML-SL111-0005 5 mg 69.00 USD
 
BML-SL111-0025 25 mg 266.00 USD
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C8-Dihydroceramide 

Negative control for C8 ceramide
145774-33-0, ≥98% (TLC) | Print as PDF
 
BML-SL113-0005 5 mg 72.00 USD
 
BML-SL113-0025 25 mg 295.00 USD
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Inhibitors

3-O-Methyl-Sphingomyelin 

Sphingomyelinase inhibitor
≥98% (TLC) | Print as PDF
 
BML-SL225-0001 1 mg 138.00 USD
 
BML-SL225-0005 5 mg 557.00 USD
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D-erythro-Sphingosine (synthetic) 

PKC inhibitor
123-78-4, ≥97% (TLC) | Print as PDF
 
ALX-306-011-M025 25 mg 73.00 USD
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D-erythro-Sphingosine chloride, N,N,N-Trimethyl- 

Inhibitor of PAF activation and PKC activity
134962-48-4, Synthetic. | Print as PDF
 
ALX-306-022-M005 5 mg 68.00 USD
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Dihydrosphingosine, D-erythro 

Sphingosine precursor
764-22-7, ≥98% (TLC) | Print as PDF
 
BML-SL125-0010 10 mg 63.00 USD
 
BML-SL125-0050 50 mg 257.00 USD
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DL-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol 

Glucosylceramide synthetase inhibitor
80938-69-8, ≥98% (TLC) | Print as PDF
 
BML-SL210-0010 10 mg 56.00 USD
 
BML-SL210-0050 50 mg 232.00 USD
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DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol 

Glucosylceramide synthetase inhibitor
149022-18-4, ≥98% (TLC) | Print as PDF
 
BML-SL215-0005 5 mg 55.00 USD
 
BML-SL215-0025 25 mg 221.00 USD
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Epoxyquinone G109 (racemic) 

N-SMase inhibitor
163972-12-1 ((+)-enantiomer), ≥98% | Print as PDF
 
ALX-270-341-M002 2 mg 217.00 USD
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Fumonisin B2 

Ceramide synthase inhibitor
116355-84-1, ≥70% (TLC) | Print as PDF
 
BML-SL219-0001 1 mg 222.00 USD
 
BML-SL219-0005 5 mg 934.00 USD
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Manumycin A 

Ras farnesyltransferase inhibitor
52665-74-4, Isolated from Streptomyces parvulus., ≥96% (HPLC) | Print as PDF
 
ALX-350-241-M001 1 mg 217.00 USD
 
ALX-350-241-M005 5 mg 653.00 USD
 
ALX-350-241-M010 10 mg 951.00 USD
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N-Butyldeoxynojirimycin . HCl 

Inhibitor of glucosylceramide synthetase and glucosidase
210110-90-0, ≥98% (TLC) | Print as PDF
 
BML-SL230-0005 5 mg 123.00 USD
 
BML-SL230-0025 25 mg 507.00 USD
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N,N-Dimethylsphingosine, D-erythro 

Sphingosine kinase inhibitor
119567-63-4, Synthetic., ≥98% (TLC) | Print as PDF
 
BML-SL105-0005 5 mg 72.00 USD
 
BML-SL105-0025 25 mg 287.00 USD
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SK1-I 

Sphingosine kinase 1 inhibitor exclusive to Enzo Life Sciences
1072443-89-0, ≥98% (HPLC) | Print as PDF
 
BML-EI411-0025 25 mg Inquire for pricing
 
BML-EI411-0005 5 mg Inquire for pricing
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SKI-II 

Sphingosine kinase inhibitor
312636-16-1, Synthetic., ≥98% (TLC) | Print as PDF
 
BML-EI406-0010 10 mg Inquire for pricing
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Sphingolactone-24 

Sphingomyelinase inhibitor
881177-99-7, ≥95% | Print as PDF
 
ALX-270-453-M001 1 mg 223.00 USD
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Sphingosine, D-erythro 

Potent and selective inhibitor of protein kinase C
123-78-4, ≥98% (TLC) | Print as PDF
 
BML-EI155-0025 25 mg 112.00 USD
 
BML-EI155-0100 100 mg 320.00 USD
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Zoledronic acid 

Acid sphingomyelinase inhibitor
165800-06-6, Synthetic., ≥98% (HPLC) | Print as PDF
 
ALX-430-153-M025 25 mg 86.00 USD
 
ALX-430-153-M100 100 mg 265.00 USD
 
ALX-430-153-G001 1 g 609.00 USD
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Ligands

BML-241 

S1P receptor ligand
298186-80-8, ≥98% | Print as PDF
 
BML-SL227-0005 5 mg 81.00 USD
 
BML-SL227-0025 25 mg 285.00 USD
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Dihydrosphingosine-1-phosphate, D-erythro 

S1P receptor ligand
28508-07-8, ≥98% | Print as PDF
 
BML-SL143-0001 1 mg 153.00 USD
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FTY-720 . HCl 

S1P receptor ligand
162359-56-0, ≥98% (HPLC) | Print as PDF
 
BML-SL233-0005 5 mg 73.00 USD
 
BML-SL233-0025 25 mg 296.00 USD
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SEW-2871 

S1P receptor ligand
256414-75-2, ≥98% | Print as PDF
 
BML-LP106-0050 50 mg 223.00 USD
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Ligand/Activator

D-erythro-Sphingosine 1-phosphate (caged) 

Synthetic., ≥95% | Print as PDF
 
ALX-306-017-C500 500 µg 199.00 USD
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Monoclonal antibody

Ceramide monoclonal antibody (MID 15B4) 

Purified from ascites by gel filtration on sephacryl S-300., ELISA, Flow Cytometry, ICC, IHC (PS) | Print as PDF
 
ALX-804-196-T050 50 tests 496.00 USD
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NKT Cell Stimulant

α-Mannosyl Ceramide 

Potent stimulator of NKT cells
≥95% (TLC and NMR) | Print as PDF
 
ALX-306-031-M001 1 mg 269.00 USD
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Polyclonal antibody

S1P1 (human) polyclonal antibody 

ICC, IP, WB | Print as PDF
 
BML-SA557-0100 100 µg 380.00 USD
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Proteins

S1P receptor 1 (rat), (membrane preparation) 

Cell membrane preparation from Rh7777 cell line transfected to overexpress S1P (EDG-1) receptor. | Print as PDF
 
BML-SE327-0050 50 assays 706.00 USD
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Saposin C (human), (recombinant) 

An essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease.
Produced in E. coli. Human recombinant saposin C (aa 309-388) is fused at the C-terminus to a His-tag and at the N-terminus to a T-7-tag., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-201-262-C050 50 µg 360.00 USD
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Sphingomyelinase (Staphylococcus aureus) 

9031-54-3, Isolated from Staphylococcus aureus. | Print as PDF
 
BML-SE108-0010 10 U 97.00 USD
 
BML-SE108-0050 50 U 389.00 USD
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Sphingosine kinase 1 (human), (recombinant) (His-tag) 

Produced in insect cells. Full length human SPHK1 is fused at the N-terminus to a His-tag. Produced in a baculovirus expression system. | Print as PDF
 
BML-SE424-0010 10 µg 500.00 USD
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Sphingosine kinase 2 (human), (recombinant) (His-tag) 

Produced in insect cells. Full length human SPHK2 is fused at the N-terminus to a His-tag. Produced in a baculovirus expression system. | Print as PDF
 
BML-SE425-0010 10 µg 500.00 USD
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Sphingolipids

C8 Ceramide-1-phosphate, D-erythro 

Ultra-pure
158983-53-0, ≥98% (TLC) | Print as PDF
 
BML-SL142-0001 1 mg 141.00 USD
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Ceramide II (bovine brain) 

Semisynthetic (from bovine brain cerebrosides)., ≥98% | Print as PDF
 
ALX-303-002-M025 25 mg 69.00 USD
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Phytosphingosine 

Ultra-pure
554-62-1, ≥98% (TLC) | Print as PDF
 
BML-SL150-0005 5 mg 74.00 USD
 
BML-SL150-0025 25 mg 316.00 USD
Do you need bulk/larger quantities?
 

Sphingomyelin 

Ultra-pure
85187-10-6, ≥98% (TLC) | Print as PDF
 
BML-SL135-0100 100 mg 98.00 USD
 
BML-SL135-0500 500 mg 401.00 USD
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