Sphingolipids are a versatile class of membrane lipid. In addition to providing mechanical stability, sphingolipids plays a role in molecular signaling, sorting and cell recognition. Therefore, a block in sphingolipid synthesis can compromise cell growth and survival. Sphingosine metabolites, such as ceramide, sphingosine, and sphingosine-1- phosphate are lipid signaling molecules which are involved in a diverse cellular processes. Sphingosine metabolites are potent mediators of cellular stress pathways, accumulation in cells can trigger growth arrest and cell death.
Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2, leading to the formation of sphingosine-1-phosphate (S1P). Sphingosine-1-phosphate is a potent signaling lipid involved in numerous biological functions including, cellular proliferation, survival, migration, invasion, differentiation, architecture, immune cell trafficking, angiogenesis and vascular integrity. Due to its diverse function, S1P has been implicated in a broad range of diseases, including atherosclerosis, respiratory distress, diabetes, cancer and inflammatory disorders.
|
C16 Ceramide C2 Ceramide C2 Dihydroceramide C6 Ceramide C6 Dihydroceramide C8 Ceramide |
Ceramide mAb DL-threo-1-Phenyl-2- Fumonisin B2 N-Butyldeoxynojirimycin . HCl |
| Research Areas | |
|
|
C16 Ceramide |
||||||
| Endogenous ceramide | ||||||
| 24696-26-2, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL115-0005 | 5 mg | 87.00 USD |  |
|||
| BML-SL115-0025 | 25 mg | 368.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C2 Ceramide |
||||||
| Cell-permeable ceramide analog | ||||||
| 3102-57-6, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL100-0005 | 5 mg | 82.00 USD | |
|||
| BML-SL100-0025 | 25 mg | 309.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C2-Phytoceramide |
||||||
| Ceramide-activated protein phosphatase activator | ||||||
| 475995-69-8, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL151-0005 | 5 mg | 348.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C6 Ceramide |
||||||
| Cell-permeable ceramide analog | ||||||
| 124753-97-5, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL110-0005 | 5 mg | 82.00 USD | |
|||
| BML-SL110-0025 | 25 mg | 367.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C8 Ceramide |
||||||
| Ceramide-activated protein kinase activator | ||||||
| 74713-59-0, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL112-0005 | 5 mg | 77.00 USD | |
|||
| BML-SL112-0025 | 25 mg | 319.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C8 ceramine, D-erythro |
||||||
| Ceramide-activated protein kinase activator | ||||||
| 170926-06-4, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL145-0001 | 1 mg | 93.00 USD | |
|||
| BML-SL145-0005 | 5 mg | 379.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Sphingosine-1-phosphate, D-erythro |
||||||
| S1P receptor agonist | ||||||
| 26993-30-6, Synthetic., ≥98% (TLC) | Print as PDF | ||||||
| BML-SL140-0001 | 1 mg | 213.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Sphingosylphosphorylcholine |
||||||
| Induces release of Ca2+ from intracellular stores | ||||||
| 82970-80-7, ≥98% (HPLC) | Print as PDF | ||||||
| BML-SL141-0010 | 10 mg | 475.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C2 Dihydroceramide |
||||||
| Negative control for C2 ceramide | ||||||
| 13031-64-6, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL101-0005 | 5 mg | 90.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C6 Dihydroceramide |
||||||
| Negative control for C6 ceramide | ||||||
| 171039-13-7, ≥98% | Print as PDF | ||||||
| BML-SL111-0005 | 5 mg | 90.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
C8-Dihydroceramide |
||||||
| Negative control for C8 ceramide | ||||||
| 145774-33-0, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL113-0005 | 5 mg | 93.00 USD | |
|||
| BML-SL113-0025 | 25 mg | 379.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
3-O-Methyl-Sphingomyelin |
||||||
| Sphingomyelinase inhibitor | ||||||
| ≥98% (TLC) | Print as PDF | ||||||
| BML-SL225-0001 | 1 mg | 182.00 USD | |
|||
| BML-SL225-0005 | 5 mg | 738.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
D-erythro-Sphingosine (synthetic) |
||||||
| PKC inhibitor | ||||||
| 123-78-4, ≥97% (TLC) | Print as PDF | ||||||
| ALX-306-011-M025 | 25 mg | 94.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Dihydrosphingosine, D-erythro |
||||||
| Sphingosine precursor | ||||||
| 764-22-7, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL125-0010 | 10 mg | 82.00 USD | |
|||
| BML-SL125-0050 | 50 mg | 347.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
DL-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol |
||||||
| Glucosylceramide synthetase inhibitor | ||||||
| 80938-69-8, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL210-0010 | 10 mg | 72.00 USD | |
|||
| BML-SL210-0050 | 50 mg | 305.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol |
||||||
| Glucosylceramide synthetase inhibitor | ||||||
| 149022-18-4, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL215-0005 | 5 mg | 73.00 USD | |
|||
| BML-SL215-0025 | 25 mg | 292.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Fumonisin B2 |
||||||
| Ceramide synthase inhibitor | ||||||
| 116355-84-1, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL219-0001 | 1 mg | 298.00 USD | |
|||
| BML-SL219-0005 | 5 mg | 1,264.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
N-Butyldeoxynojirimycin . HCl |
||||||
| Inhibitor of glucosylceramide synthetase and glucosidase | ||||||
| 210110-90-0, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL230-0005 | 5 mg | 160.00 USD | |
|||
| BML-SL230-0025 | 25 mg | 685.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
N,N-Dimethylsphingosine, D-erythro |
||||||
| Sphingosine kinase inhibitor | ||||||
| 119567-63-4, Synthetic., ≥98% (TLC) | Print as PDF | ||||||
| BML-SL105-0005 | 5 mg | 94.00 USD | |
|||
| BML-SL105-0025 | 25 mg | 370.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
SK1-I |
||||||
| Sphingosine kinase 1 inhibitor exclusive to Enzo Life Sciences | ||||||
| 1072443-89-0, ≥98% (HPLC) | Print as PDF | ||||||
| BML-EI411-0025 | 25 mg | Inquire for pricing | ||||
| BML-EI411-0005 | 5 mg | Inquire for pricing | ||||
| Do you need bulk/larger quantities? | ||||||
SKI-II |
||||||
| Sphingosine kinase inhibitor | ||||||
| 312636-16-1, Synthetic., ≥98% (TLC) | Print as PDF | ||||||
| BML-EI406-0010 | 10 mg | 93.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Sphingolactone-24 |
||||||
| Sphingomyelinase inhibitor | ||||||
| 881177-99-7, ≥95% | Print as PDF | ||||||
| ALX-270-453-M001 | 1 mg | 295.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Sphingosine, D-erythro |
||||||
| Potent and selective inhibitor of protein kinase C | ||||||
| 123-78-4, ≥98% (TLC) | Print as PDF | ||||||
| BML-EI155-0025 | 25 mg | 145.00 USD | |
|||
| BML-EI155-0100 | 100 mg | 423.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Zoledronic acid |
||||||
| Acid sphingomyelinase inhibitor | ||||||
| 165800-06-6, Synthetic., ≥98% (HPLC) | Print as PDF | ||||||
| ALX-430-153-M025 | 25 mg | 112.00 USD | |
|||
| ALX-430-153-M100 | 100 mg | 349.00 USD | |
|||
| ALX-430-153-G001 | 1 g | 784.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Dihydrosphingosine-1-phosphate, D-erythro |
||||||
| S1P receptor ligand | ||||||
| 28508-07-8, ≥98% | Print as PDF | ||||||
| BML-SL143-0001 | 1 mg | 201.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
FTY-720 . HCl |
||||||
| S1P receptor ligand | ||||||
| 162359-56-0, ≥98% (HPLC) | Print as PDF | ||||||
| BML-SL233-0005 | 5 mg | 94.00 USD | |
|||
| BML-SL233-0025 | 25 mg | 391.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
SEW-2871 |
||||||
| S1P receptor ligand | ||||||
| 256414-75-2, ≥98% | Print as PDF | ||||||
| BML-LP106-0050 | 50 mg | 295.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
D-erythro-Sphingosine 1-phosphate (caged) |
||||||
| Synthetic., ≥95% | Print as PDF | ||||||
| ALX-306-017-C500 | 500 µg | 268.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Ceramide monoclonal antibody (MID 15B4) |
||||||
| Purified from ascites by gel filtration on sephacryl S-300., ELISA, Flow Cytometry, ICC, IHC (PS) | Print as PDF | ||||||
| ALX-804-196-T050 | 50 tests | 657.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
α-Mannosyl Ceramide |
||||||
| Potent stimulator of NKT cells | ||||||
| ≥95% (TLC and NMR) | Print as PDF | ||||||
| ALX-306-031-M001 | 1 mg | 353.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
S1P1 (human) polyclonal antibody |
||||||
| ICC, IP, WB | Print as PDF | ||||||
| BML-SA557-0100 | 100 µg | 410.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Saposin C (human), (recombinant) |
||||||
| An essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease. | ||||||
| Produced in E. coli. Human recombinant saposin C (aa 309-388) is fused at the C-terminus to a His-tag and at the N-terminus to a T-7-tag., ≥95% (SDS-PAGE) | Print as PDF | ||||||
| ALX-201-262-C050 | 50 µg | 472.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Sphingomyelinase (Staphylococcus aureus) |
||||||
| 9031-54-3, Isolated from Staphylococcus aureus. | Print as PDF | ||||||
| BML-SE108-0010 | 10 U | 129.00 USD | |
|||
| BML-SE108-0050 | 50 U | 523.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Ceramide II (bovine brain) |
||||||
| Semisynthetic (from bovine brain cerebrosides)., ≥98% | Print as PDF | ||||||
| ALX-303-002-M025 | 25 mg | 90.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Phytosphingosine |
||||||
| Ultra-pure | ||||||
| 554-62-1, ≥98% (TLC) | Print as PDF | ||||||
| BML-SL150-0005 | 5 mg | 95.00 USD | |
|||
| BML-SL150-0025 | 25 mg | 418.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
Sphingomyelin |
||||||
| Ultra-pure | ||||||
| 85187-10-6, Purified from bovine spinal cord., ≥98% (TLC) | Print as PDF | ||||||
| BML-SL135-0100 | 100 mg | 131.00 USD | |
|||
| BML-SL135-0500 | 500 mg | 539.00 USD | |
|||
| Do you need bulk/larger quantities? | ||||||
