NGAL (also known as Lipocalin-2 or Neutrophil Gelatinase-associated Lipocalin) is a small, ~25kDa secreted protein expressed in epithelial tissues and released into both urine and blood upon kidney tubular damage. The protein is protease resistant and over-expressed during inflammation, infection and certain cancers. During acute renal failure (ARF) caused by either ischemia or nephrotoxicity, NGAL is secreted in high levels into blood and urine within 2 hours or less of injury to the kidney. NGAL is also released at the time of acute kidney injury (AKI) unlike serum creatinine, another kidney diagnostic biomarker which may not be seen until 72 hours after injury when up to 50% of renal function may have been lost.
Drug-induced acute kidney injury account for as much as 25% of all episodes of acute renal failure - a serious problem in clinical medicine as well as in the pharmaceutical industry. In drug development, some therapeutic candidates fail due to unexpected toxic effects in the kidneys, resulting in adverse outcomes and ultimately development termination of these candidates (attrition).
NGAL provides an excellent endogenous biomarker for acute kidney injury (AKI) which occurs prior to ARF. Changes in NGAL urine and blood can be used to assess kidney status as a supplement to other established medical products or procedures.
“An appropriate preclinical biomarker-based strategy facilitates selection of drug candidates with improved kidney safety profile” - Burt D et al. (2013) Drug Chem Toxicol. Oct 16. Epub ahead of print
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Versatile BioPorto® ELISA kits for detection of NGAL in variety of species and sample types.
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Human NGAL Rapid ELISA Kit - Calibration Curve |
NGAL (human) ELISA kit |
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| Highly sensitive ELISA, measuring as little as 4 pg/ml of NGAL | ||||||
| ELISA, Colorimetric detection | Print as PDF | ||||||
| BPD-KIT-036 | 96 wells | 911.00 USD |  |
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NGAL (dog) ELISA kit |
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| ELISA, Colorimetric detection | Print as PDF | ||||||
| BPD-KIT-043 | 96 wells | 1,039.00 USD | |
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NGAL (monkey) ELISA kit |
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| ELISA, Colorimetric detection | Print as PDF | ||||||
| BPD-KIT-045 | 96 wells | 1,778.00 USD | |
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NGAL (mouse) ELISA kit |
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| ELISA, Colorimetric detection | Print as PDF | ||||||
| BPD-KIT-042 | 96 wells | 851.00 USD | |
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NGAL (pig) ELISA kit |
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| ELISA, Colorimetric detection | Print as PDF | ||||||
| BPD-KIT-044 | 96 wells | 1,002.00 USD | |
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