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Metabolism

Transform Your Metabolic Research


  • Adiponectin
  • Adiponectin Receptor Activation
  • Induction & Analysis of Adipogenesis

  • Mitochondrial Function
  • MMP Loss
  • Quantify Glutathione

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Metabolism Brochure

Tools for Advancing your Metabolic Research

Metabolism refers to a set of chemical reactions which are responsible for transforming carbohydrates, lipids and proteins into energy. These biochemical processes are essential for maintaining homeostasis. Metabolic research focuses on better understanding basic biological mechanisms that regulate metabolism and how they are dysregulated in disorders such as obesity, diabetes, cardiovascular disease, and cancer. A common root cause in these medical conditions is an energy imbalance; better understanding of this disparity will help determine therapeutic strategies. Even though metabolism involves sequences of complex biochemical reactions, Enzo Life Sciences provides simple and novel solutions to advance your metabolic research.


 

Discover, Analyse & Quantify Metabolic Biomarkers

Adiponectin

Adiponectin is a protein hormone primarily produced by adipocytes which circulates at high levels (5-30 mg/L) in the blood. Adiponectin modulates a number of metabolic processes and is known to contribute to metabolic pathologies including diabetes, atherosclerosis, and obesity. It has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation.

 

Modulation of Glucose & Lipid Metabolism

Recombinant Human Adiponectin

HMW Adiponectin Delivering Superior In Vitro Activity

Quantify Adiponectin

Adiponectin (human), ELISA Kit

A Rapid, High-sensitivity ELISA Kit for Quantification of Human Adiponectin

Adiponectin Receptor Activation

AdipoRon

A Novel Small Molecule Adiponectin Mimetic

Induction & Analysis of Adipogenesis

Adipogenesis Assay Kit

Convenient Method For the Enhanced Induction and Detection of Adipogenesis

Adipogenesis Dye Allows for Visual Confirmation of Adipocyte Differentiation



3T3-L1 cells were treated with and without induction media. After 10 days, cells were stained with Adipogenesis Dye and imaged at 40x magnification.









Obesity

Obesity is associated with a low-grade inflammation of white adipose tissue (WAT) resulting from chronic activation of the innate immune system. Downstream, this can lead to insulin resistance, impaired glucose tolerance and even diabetes. Understanding the mechanisms leading to disease will help in developing new approaches to its treatment and prevention.

 

GLP and Exendin

GLP (glucagon-like peptide) functions in the regulation of blood glucose through insulin, and plays a role in obesity and diabetes. GLP-1 is an important gastrointestinal peptide hormone or incretin, which is released when we eat, produced by tissue specific post-translational processing from a glucagon precursor, and inactivated by dipeptidylpeptidase DPP-4 enzymes. Exendin-4 is a 39 amino-acid peptide found in venom from the Gila monster. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. As an agonist of the GLP-1 receptor, Exendin-4 is a potent stimulator of insulin secretion and has a much longer half life than GLP-1 (~2 minutes) making it a suitable drug candidate for the treatment of obesity and type-2 diabetes.

  • Amp’d® GLP-1 ELISA Kit
  • GLP Antibodies
  • Exendin Antibodies
  • GLP Proteins
  • Exendin-4 Protein


Lipocalin-2, Neutrophil Gelatinase-associated Lipocalin (NGAL)

NGAL (also known as Lipocalin-2 or Neutrophil Gelatinase-associated Lipocalin) is a small, ~25kDa secreted protein expressed in epithelial tissues and released into both urine and blood upon kidney tubular damage. The protein is protease resistant and over-expressed during inflammation, infection and certain cancers. During acute renal failure (ARF) caused by either ischemia or nephrotoxicity, NGAL is secreted in high levels into blood and urine within 2 hours or less of injury to the kidney. NGAL is also released at the time of acute kidney injury (AKI) unlike serum creatinine, another kidney diagnostic biomarker which may not be seen until 72 hours after injury when up to 50% of renal function may have been lost.

  • NGAL ELISA Kits
  • NGAL Antibodies
  • NGAL Proteins


Adipokines

Adipose tissue contains differentiated cells called adipocytes that are specialized in storing fat. In addition to their function in controlling energy homeostasis, adipocytes release endocrine and paracrine signaling molecules called adipokines that are important in many physiological and metabolic processes. Some adipokines such as adiponectin, omentin, Nampt (Visfatin/PBEF), vaspin, resistin or RBP4 are involved in insulin signaling. Others regulate food intake and lipid metabolism (e.g. leptin, chemerin).

Empower Your Research with our Innovative Platforms

Mitochondria, the organelles that generate energy for the cell, have a critical role in the function of a cell. Mitochondrial disease, stemming from dysfunction, can have various effects on the body with conditions ranging from epilepsy, psychiatric illness and autism, to cardiovascular disease, liver/kidney disease, diabetes and cancer. The impact of mitochondria in so many diseases makes them ideal targets for new therapeutics.

 

Mitochondrial Function

Mito-ID® Extracellular pH Sensor Probe

Efficiently Monitor Glycolytic Activity

  • pH sensitive probe increases in signal intensity with increasing acidity
  • Simple mix-and-read protocol for 96-well microplates.

Mito-ID® Extracellular O2 Sensor Kit High Sensitivity

Detect Mitochondrial Dysfunction Within Minutes of Treatment

  • Phosphorescent probe increases in signal intensity with O2 consumption (diminishing O2 levels)
  • Amenable to 96- and 384-well microplates for high-throughput analysis
  • Multiplex with Mito-ID® pH Sensor probe to confirm mitochondrial toxicity

Mito-ID® Assays to Identify True Mitochondrial Toxicity



Multi-compound Screening using Mito-ID® Extracellular O2 Sensor Kit and Mito-ID® Extracellular pH Sensor Probe. Compound 2 shows a dose dependent effect on oxygen consumption (decrease) with an increase in acidification representing "True" mitochondrial toxicity.

MMP Loss

Mito-ID® Membrane Potential Detection Kit for Microscopy and Flow Cytometry

The Only Assay that Monitors Energetic Status Using a Simple Mix-and-Read, No-Wash Protocol


Mito-ID® Membrane Potential Cytotoxicity Kit for Microplates

A Real-time Mitochondrial Membrane Potential Assay with Superior Sensitivity


Detect MMP Perturbations with 10X More Sensitivity than JC-1



Quantify Glutathione

Glutathione (GSSG/GSH), Detection Kit

Rapid, Ultra-sensitive Kit for the Quantification of Reduced (GSH), Oxidized (GSSG), and Total Glutathione

  • High sensitivity assay based on an enzymatic recycling reaction for measuring total, oxidized or reduced glutathione
  • Easy-to-use, rapid kit with sample handling protocols for a wide variety of matrices
  • Fast, accurate assay results in less than 30 minutes

Ultra-sensitive Detection and Analysis of Glutathione


Detect Metabolic Analytes Accurately & Efficiently

Dysregulation in metabolic pathways results in some of the most devastating global healthcare challenges we face today such as obesity, diabetes, cardiovascular disease and cancer. Metabolic biomarkers play an important role in both diagnosis and prognosis.

 

Simplify Your Research With ELISA Kits

Built upon our diverse scientific expertise and technology platforms, Enzo solutions enable you to advance your metabolic research with more than 250 ELISA kits for accurate detection of your specific analyte.

Chemerin ELISA Kit

  • Sensitive detection down to 0.1 ng/ml of chemerin
  • Rapid results in < 3.5 hours

FABP4 ELISA Kit

  • Sensitive detection down to 0.05 ng/ml of FABP4
  • Rapid results in < 4 hours

25 (OH) Vitamin D ELISA

  • Sensitive detection down to 1.98 ng/ml of
    25 (OH) Vitamin D
  • Rapid results in < 1.5 hours

sRAGE ELISA Kit

  • Sensitive detection down to 19.2 ng/ml of sRAGE
  • Rapid results in < 4.5 hours

Related Literature and Documents

Latest Literature

Product Flyers
Transform Your Metabolic Research
Transform Your Metabolic Research 17-Jun-14
Download as PDF
Catalogs
Diabetes Catalog
Diabetes Catalog 14-Jun-10
Download as PDF
Catalogs
Obesity Catalog
Obesity Catalog 18-May-09
Download as PDF
 

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