Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Metabolism

Understanding of the body

Metabolism research is crucial to the understanding of the body. It is well known that a variety of metabolic challenges are brought about by obesity and diabetes. Research over the past decade has redefined adipose tissue as more than just a metabolic storehouse; it is now recognized as an active metabolic organ, serving as the source of numerous adipokines and secreted factors that act as mediators of not only obesity, but also insulin resistance, hypertension, diabetes, atherosclerosis, and cancer. Research in bone metabolism is key to the understanding of bone remodeling, resorption, osteoporosis & chondrogenesis.

 

Key Proteins & Peptides

Lipocalin-2, Neutrophil Gelatinase-associated Lipocalin (NGAL)

NGAL (also known as Lipocalin-2 or Neutrophil Gelatinase-associated Lipocalin) is a small, ~25kDa secreted protein expressed in epithelial tissues and released into both urine and blood upon kidney tubular damage. The protein is protease resistant and over-expressed during inflammation, infection and certain cancers. During acute renal failure (ARF) caused by either ischemia or nephrotoxicity, NGAL is secreted in high levels into blood and urine within 2 hours or less of injury to the kidney. NGAL is also released at the time of acute kidney injury (AKI) unlike serum creatinine, another kidney diagnostic biomarker which may not be seen until 72 hours after injury when up to 50% of renal function may have been lost.

  • NGAL ELISA Kits
  • NGAL Antibodies
  • NGAL Proteins


GLP and Exendin

GLP (glucagon-like peptide) functions in the regulation of blood glucose through insulin, and plays a role in obesity and diabetes. GLP-1 is an important gastrointestinal peptide hormone or incretin, which is released when we eat, produced by tissue specific post-translational processing from a glucagon precursor, and inactivated by dipeptidylpeptidase DPP-4 enzymes.

Exendin-4 is a 39 amino-acid peptide found in venom from the Gila monster. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. As an agonist of the GLP-1 receptor, Exendin-4 is a potent stimulator of insulin secretion and has a much longer half life than GLP-1 (~2 minutes) making it a suitable drug candidate for the treatment of obesity and type-2 diabetes.


 

Obesity & Adipokines

Obesity is primarily characterized by an excessive fat accumulation that may impair health. Adipose tissue contains differentiated cells called adipocytes that are specialized in storing fat. In addition to their function in controlling energy homeostasis, adipocytes release endocrine and paracrine signaling molecules called adipokines that are important in many physiological and metabolic processes. Some adipokines such as adiponectin, omentin, Nampt (Visfatin/PBEF), vaspin, resistin or RBP4 are involved in insulin signaling. Others regulate food intake and lipid metabolism (e.g. leptin, chemerin).


 

Cardiovascular

Discover, Analyze, Quantify Cardiovascular Biomarkers

Cardiovascular disease is consistently ranked as the single largest cause of death in the world, and it may be caused by heart damage or vascular problems. Challenges in cardiovascular clinical development have caused researchers to take a closer look at cardiac function and metabolism. Enzo Life Sciences offers a comprehensive portfolio of products to enable discovery of cardiac risk factors as well as analysis of the cellular response to novel therapeutics for cardiovascular medicine.


 

Related Literature and Documents

Latest Literature

Catalogs
Diabetes Catalog
Diabetes Catalog 14-Jun-10
Download as PDF
Catalogs
Obesity Catalog
Obesity Catalog 18-May-09
Download as PDF
 

Recommend this page

 
Keep in touch

©2014 Enzo Life Sciences, Inc.,