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Immune & Inflammation Signaling


  • Cytokine & Interleukin ELISAs
  • Eicosanoid ELISAs
  • Prostaglandin Analysis



Overview of Inflammation

Inflammation is the biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. One of the major intracellular regulators of inflammation is the transcription factor NF-κB which upregulates the expression of cytokines and adhesion molecules. Chronic inflammation can lead to various diseases, such as Alzheimer’s disease, autoimmune disorders and cancer. Systemic inflammation is not confined to a particular tissue, but involves the endothelium and other organ systems. High levels of inflammation-related markers such as IL-6, IL-8, and TNF-α are associated with obesity.

 

Cytokine & Eicosanoid ELISA Kits

Cytokines are secreted signaling molecules that mediate and regulate immunity, inflammation and many developmental processes during embryogenesis. Cytokines can have pleiotropic, overlapping, and sometimes contradictory functions, and also play an important role in angiogenesis  and cancer. Eicosanoids are a group of biologically active oxygenated unsaturated fatty acids derived from arachidonic acid by the action of cyclooxygenases, lipoxygenases, and cytochrome P450 mono-oxygenases. The eicosanoid family includes prostaglandins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and lipoxins. Eicosanoids have been shown to enhance, as well as attenuate inflammation and have also been linked to carcinogenesis.


Enzo’s portfolio of ELISA kits for cytokines and eicosanoids features:

  • Over 100 sensitive ELISAs for quantifying cytokines and eicosanoids
  • Over 20 years of ELISA development and manufacturing experience
  • Widely cited in peer-reviewed publications
  • Low cost-per-test, high-throughput, multi-plate pack sizes available
  • Time-saving, easy-to-use kits with results in less than 3 hours

 

Cytokine & Interleukin ELISAs

Broad portfolio of sensitive, high-specificity ELISA kits for human and rodent cytokines and interleukins.

Eicosanoid ELISAs

Widely cited, ultrasensitive eicosanoid ELISA kits built upon over 20 years of small molecule ELISA development and manufacturing expertise.

Prostaglandin Analysis

Enzo is a trusted manufacturer of ELISA kits, antibodies and high-purity bioactive lipids and enzymes for the analysis of PGE2 and other prostaglandins.

Featured Product

  • Ultrasensitive – measure as little as 8.26 pg/ml PGE2
  • Flexible – validated in a wide variety of sample matrices
  • Reliable – obtain reproducible results lot-after-lot and day-after-day
  • Cost-effective – available in 1x96 and 5x96 well package size
 
 

MBL - Mannan-Binding Lectin

MBL (Mannan-Binding Lectin) is a carbohydrate-binding protein produced in the liver and secreted into the blood. The protein plays a key factor in innate immunity, functioning as a player in the complement activation cascade and defending the body against invading microorganisms (bacteria, viruses, protozoa and fungi).


 

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