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Immunology

Innovative Products to Analyze Immunological Disorders


  • TLRgrade™ LPS & Lipid A Reagents
  • Worry-Free Antibodies



  • Native Bacterial and Viral Antigens
  • Factors for Modulating the Host Response
  • Detect and Identify Viral Infection



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Immunology Brochure

Tip The Balance In Your Favor

Comprehensive Tools for Interpreting Immunological Responses

Maintaining the proper balance between immune activation and suppression is critical for physiological functioning of the innate and adaptive immune system. Disruption of this equilibrium leads to immunological disorders including autoimmune diseases, hypersensitivities, and immune deficiency. Enzo Life Sciences provides a comprehensive portfolio of products to detect and modulate the complex processes of immunological disease.

 

High Purity Ligands & Antibodies for Infectious Disease

Toll-like Receptors

Providing the purest ligands for recognition by pattern recognition receptors.

 

TLRgrade™ LPS & Lipid A Reagents

  • Ultrapure (≥99.9%)
  • Sterile, ready-to-use liquid formulation
  • No hazardous handling

TLRgrade LPS & Lipid A Reagents

Worry-Free Antibodies

Enzo offers over 50 TLR antibodies validated for flow cytometry and microscopy applications.


TLR antibodies
 

Monitor Activity Of Therapeutic Compounds

High-throughput Screening for Multidrug Resistance

  • Quantitative measurements of multidrug resistance activity in live cells
  • Simple and reproducible mix-and-read protocol optimized for flow cytometry
  • Two dye formats allows multiplexing

High-throughput Screening for Multidrug Resistance

The Only Assay for Functional Detection of All Three Clinically Relevant ABC Transporter Proteins


Profiling of ABC transporter activity by known inhibitors was assessed in CHO K1 cells using eFluxx-ID® Green and eFluxx-ID® Gold dyes.

 

Toolset For Diagnostics & Vaccine Development

Native Bacterial and Viral Antigens

Optimized Expression Systems Deliver Superior Antigenicity
We offer a broad range of native state bacterial and viral antigens for vaccine research and in vitro diagnostics markets. Purified native protein or production in the latest mammalian expression systems ensure that the resultant antigens are expressed to a high level, are in their native folded state, and possess all relevant post-translational modifications.

  • Higher specificity and sensitivity
  • Minimal lot-to-lot variation
  • Reproducible scale-up for bulk quantities
  • Lyophilized format for extended shelf-life

Native Bacterial and Viral Antigens

Highly Virulent Bacterial Toxins

B. pertussis
C. difficile
C. diphtheria
C. trachomatis
M. pneumonia
N. gonorrhoeae
T. vaginalis
V. cholera

 

Factors for Modulating the Host Response

Superior Performance From Carefully Engineered TNF Superfamily Ligands

MegaCD40L® (soluble) (human), (recombinant)

  • Highly purified protein minimizes unwanted immune activation
  • Consistent performance in lot-to-lot testing
  • Optimized formulation for improved stability and enhanced activity


Engineered TNF Superfamily Ligands

Enhance Immune Activation with MegaCD40L®

B cell lymphocyte activation by various CD40L constructs. PBMCs were treated for 48 hrs in media containing serially diluted MegaCD40L, CD40L + 2ug/mL Enhancer, or CD40L. Cells were dual-stained with α-human CD19–PE and α -human CD86–APC and analyzed by flow cytometry. Data are presented as the percent of CD19+ B cells that co-stain as CD86+.

 
 

Detect and Identify Viral Infection

PathoGene® Products
HPV probes and typing assays for sensitive detection of pathogen-expressed genes from fresh or FFPE tissue sections.


PathoGene HPV probes

BioProbe® Products
Biotinylated probes prepared by nick translation for specific detection of:

Adenovirus
BK Virus
Cytomegalovirus
Herpes Simplex
Hepatitis A Virus
JC Virus
SV 40

BioProbe Biotinylated probes
 

Quantify Biomarkers Of Inflammation With ELISAs

Cytokine & Eicosanoid

Cytokines are secreted signaling molecules that mediate and regulate immunity, inflammation and many developmental processes during embryogenesis. Cytokines can have pleiotropic, overlapping, and sometimes contradictory functions, and also play an important role in angiogenesis  and cancer. Eicosanoids are a group of biologically active oxygenated unsaturated fatty acids derived from arachidonic acid by the action of cyclooxygenases, lipoxygenases, and cytochrome P450 mono-oxygenases. The eicosanoid family includes prostaglandins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and lipoxins. Eicosanoids have been shown to enhance, as well as attenuate inflammation and have also been linked to carcinogenesis.


Enzo’s portfolio of ELISA kits for cytokines and eicosanoids features:

  • Over 100 sensitive ELISAs for quantifying cytokines and eicosanoids
  • Over 20 years of ELISA development and manufacturing experience
  • Widely cited in peer-reviewed publications
  • Low cost-per-test, high-throughput, multi-plate pack sizes available
  • Time-saving, easy-to-use kits with results in less than 3 hours

 

Cytokine ELISAs

Broad portfolio of sensitive, high-specificity ELISA kits for human and rodent cytokines.

Eicosanoid ELISAs

Widely cited, ultrasensitive eicosanoid ELISA kits built upon over 20 years of small molecule ELISA development and manufacturing expertise.

Prostaglandin Analysis

Enzo is a trusted manufacturer of ELISA kits, antibodies and high-purity bioactive lipids and enzymes for the analysis of PGE2 and other prostaglandins.

C-Reactive Protein

C-Reactive Protein (CRP) is a pentraxin family protein that is widely used as a biomarker for systemic inflammation and tissue injury. Its primary role in innate immunity is to function as an opsonin for pathogens via activation of the complement pathway and through binding to Fc gamma receptors. CRP has been shown to play an important role in a variety of pathological pathways.

 

CRP, ELISA Kit

  • Sensitive assay detects as little as 12.685 ng/ml in serum and plasma
  • Highly specific with negligible reactivity to other family members
  • Rapid results in just 1.5 hours

Typical standard curve shows broad range of detection

 

Detect Specific Cells With CD Markers Antibodies

Enzo Life Sciences offers a broad range of antibodies for use in all areas of immunology. Many are validated for use in key applications such as flow cytometry, immunohistochemistry, immunoprecipitation and Western blotting. Every antibody is backed by our Worry-free Antibody Trial Program, allowing you to evaluate any of our antibodies of interest for your specific application or species without risk.

 
CD Marker T Cells B Cells Dendritic Cells NK Cells Stem Cell
Precursors
Macrophages Granulocytes Platelets Erythrocytes Endothelial
Cells
Epithetial
Cells
CD3 Find
CD4 Find Find Find
CD9 Find Find Find Find Find Find Find Find
CD11a Find Find Find Find Find
CD18 Find Find Find Find Find Find Find
CD20 Find Find
CD23 Find Find Find Find Find Find Find
CD26 Find Find Find Find Find
CD31 Find Find Find Find Find Find Find
CD36 Find Find Find Find Find Find
CD38 Find Find Find Find Find Find
CD38 Find Find Find Find Find Find
CD39 Find Find Find Find Find Find Find
CD40 Find Find Find Find Find Find Find Find
CD40L Find
CD41 Find Find Find
CD41a Find Find
CD41b Find Find
CD42 Find Find
CD42 complex Find Find
CD44 Find Find Find Find Find Find Find Find
CD45 Find Find Find Find Find Find Find
CD45RA Find Find Find Find Find Find
CD49b/CD29 Find Find Find Find Find Find Find Find Find Find
CD49f Find Find Find Find Find Find
CD51 Find Find Find
CD54 Find Find Find Find
CD66a Find Find
CD66b Find
CD66c Find Find
CD66e Find
CD68 Find Find Find Find Find Find
CD74 Find Find Find Find Find Find
CD80 Find Find Find Find
CD83 Find Find Find
CD87 Find Find Find Find Find
CD107b Find Find Find
CD123 Find Find Find Find
CD127 Find Find Find
CD163 Find
CD194 Find Find Find Find Find Find
CD205 Find Find Find
CD207 Find
CD208 Find
CD223 Find Find Find
CD243 Find
CD324 (E-cadherin) Find Find Find Find
CD325 Find


Discover over 150 CD Antibodies validated for Flow Cytometry

MBL - Mannan-Binding Lectin

MBL (Mannan-Binding Lectin) is a carbohydrate-binding protein produced in the liver and secreted into the blood. The protein plays a key factor in innate immunity, functioning as a player in the complement activation cascade and defending the body against invading microorganisms (bacteria, viruses, protozoa and fungi).



MBL - Mannan-Binding Lectin
 

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