Autophagic activity is critical to the maintenance of cellular homeostasis and energy balance. Although typically low under basal conditions, autophagy can be markedly upregulated by a variety of physiological stimuli such as nutrient starvation, hypoxia, endoplasmic reticulum stress, as well as immune and hormonal stimulation. With our innovative assays and reagents, Enzo enables scientists to gain a deeper understanding of the benefits, and potential consequences, of altering autophagic activity.
Apoptosis (PCD Type 1) is the most-well characterized, being recognized as a critical regulator of development, immunity, as well as organ and tissue homeostasis. Apoptotic cells die in a controlled fashion in response to a variety of extrinsic or intrinsic signals (e.g., activation of TNF receptors, DNA damage, mitochondrial pathways). With over 2000 products for the analysis of cell death, Enzo enables detection of phenotypic hallmarks of apoptotic cell death.
Of the three major established programmed cell death (PCD) pathways, Apoptosis (PCD Type 1) is the most-well characterized, being recognized as a critical regulator of development, immunity, as well as organ and tissue homeostasis. Apoptotic cells die in a controlled fashion in response to a variety of extrinsic or intrinsic signals.
Detect Hallmarks Of Apoptosis
Wide range of products for the study of Membrane Display Of Phosphatidylserine, Chromatin Condensation, DNA Damage.
Modulate & Screen Caspase Activity
High-purity inhibitors, active enzymes, antibodies and flexible activity assays for complete analysis of caspase cascades. Including Caspase Activity Assays & Active Enzymes, Ready-to-Use Caspase Inhibitors & Antibody-Based Detection of Cleaved Caspases.
Extrinsic Signaling Through Death Receptors
Superior performance from carefully engineered TNF Superfamily Ligands. Discover the power of oligomerized domains in Enzo Enhanced Ligands
Mitochondrial Perturbations & Intrinsic Activation
High-Throughtput Assays for Mitochondrial Function. A real-time mitochondrial membrane potential assay with superior sensitivity
Autophagy (literally “self-eating”) is a lysosome-mediated intracellular bulk degradation pathway employed by eukaryotic cells when subjected to certain hostile conditions (such as nutrient deprivation) that triggers digestion and recycling of cellular contents.
Immunoassay Kits
Sensitive ELISA kits for measuring autophagy biomarkers NBR1 and p62.
Library and Small Molecules
Wide selection of small molecule activators and inhibitors of autophagy, including our curated Autophagy Compound Library.
CELLESTIAL™ Live Cell Analysis Kits
Robust live cell analysis kits for quantitative detection of autophagy, aggresomes, lysosomal perturbations, and more.
An Introduction into Regulated Cell Death
2021 December 17 | Tags:
Autophagy,
Cell Death
How to Differentiate Between Cell Death Types?
2020 December 11 | Tags:
Apoptosis, Cell Death
, Successful Research Tips
10 Tips for successful flow cytometry
2015 February 20 | Tags:
Apoptosis,
Autophagy,
Cancer,
Cell Death,
Inflammation,
Immunity,
Oxidative Stress,
Screening,
Stem Cells,
Successful Research Tips,
We Are Enzo!
The Best Defense Against Multidrug Resistance
2014 December 12 | Tags:
Apoptosis,
Cancer,
Cell Death,
Drug Discovery,
Screening,
Toxicology
Novel biomarker for monitoring neuronal death and Alzheimer’s disease progression
2014 November 28 | Tags:
Apoptosis,
Cell Death,
Neuroscience,
Screening,
Toxicology
Imbalance in TNF-α signaling aggravates cisplatin-induced nephrotoxicity
2014 September 5 | Tags:
Apoptosis,
Autophagy,
Toxicology
Resist the Signs of Aging with Autophagy
2014 July 29 | Tags:
Autophagy,
Personal Care
It is not too late to make a New Year’s resolution: Exercise more
2014 January 24 | Tags:
Apoptosis,
Cell Death,
Metabolism
Infographic - Personal care, an ever growing market
2013 December 6 | Tags:
Cancer,
Inflammation,
Oxidative Stress,
Personal Care,
Toxicology
For those about to ROCK (we detach you)
2013 September 20 | Tags:
Apoptosis,
Cell Death
