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Cell Death

Monitor programmed cell death from membrane to nucleus




Monitor programmed cell death

Monitor programmed cell death from membrane to nucleus

Autophagic activity is critical to the maintenance of cellular homeostasis and energy balance. Although typically low under basal conditions, autophagy can be markedly upregulated by a variety of physiological stimuli such as nutrient starvation, hypoxia, endoplasmic reticulum stress, as well as immune and hormonal stimulation. With our innovative assays and reagents, Enzo enables scientists to gain a deeper understanding of the benefits, and potential consequences, of altering autophagic activity.

Apoptosis (PCD Type 1) is the most-well characterized, being recognized as a critical regulator of development, immunity, as well as organ and tissue homeostasis. Apoptotic cells die in a controlled fashion in response to a variety of extrinsic or intrinsic signals (e.g., activation of TNF receptors, DNA damage, mitochondrial pathways). With over 2000 products for the analysis of cell death, Enzo enables detection of phenotypic hallmarks of apoptotic cell death.

 

Apoptosis

Complete Analysis of Apoptosis and Cell Fate

Of the three major established programmed cell death (PCD) pathways, Apoptosis (PCD Type 1) is the most-well characterized, being recognized as a critical regulator of development, immunity, as well as organ and tissue homeostasis. Apoptotic cells die in a controlled fashion in response to a variety of extrinsic or intrinsic signals.


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Monitor programmed cell death from membrane to nucleus
 

Detect Hallmarks Of Apoptosis
Wide range of products for the study of Membrane Display Of Phosphatidylserine, Chromatin Condensation, DNA Damage.

Modulate & Screen Caspase Activity
High-purity inhibitors, active enzymes, antibodies and flexible activity assays for complete analysis of caspase cascades. Including Caspase Activity Assays & Active Enzymes, Ready-to-Use Caspase Inhibitors & Antibody-Based Detection of Cleaved Caspases.

 

Extrinsic Signaling Through Death Receptors
Superior performance from carefully engineered TNF Superfamily Ligands. Discover the power of oligomerized domains in Enzo Enhanced Ligands

Mitochondrial Perturbations & Intrinsic Activation
High-Throughtput Assays for Mitochondrial Function. A real-time mitochondrial membrane potential assay with superior sensitivity

 

Autophagy

Enabling a Clearer Understanding of Autophagy and Disease Through Innovative Assays

Autophagy (literally “self-eating”) is a lysosome-mediated intracellular bulk degradation pathway employed by eukaryotic cells when subjected to certain hostile conditions (such as nutrient deprivation) that triggers digestion and recycling of cellular contents.


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Autophagy
 

Immunoassay Kits
Sensitive ELISA kits for measuring autophagy biomarkers NBR1 and p62.

Library and Small Molecules
Wide selection of small molecule activators and inhibitors of autophagy, including our curated Autophagy Compound Library.

CELLESTIAL™ Live Cell Analysis Kits
Robust live cell analysis kits for quantitative detection of autophagy, aggresomes, lysosomal perturbations, and more.

 

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