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Pigmentation

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Sensitive Detection for Modulators of Pigmentation

Binding of Melanocyte Stimulating Hormone (MSH) to the melanocortin 1 receptor (MC1R, a GS-protein coupled receptor) on melanocytes triggers pro-differentiation signals mediated by the second messenger cyclic AMP (cAMP). cAMP-mediated signals inhibit UV-induced apoptosis and promote melanin synthesis via transcriptional activation of pigment regulating enzymes such as tyrosinase. Modulation of cAMP levels by pharmacological induction of adenylate cyclases, or inhibition of phosphodiesterases, hold promise as UV-independent mechanisms of increasing natural production of melanin and protection from UV damage to skin.

 

Cyclic Nucleotide Analysis

Enzo Life Sciences offers the most sensitive and complete colorimetric ELISA kits for quantification of intracellular or extracellular cAMP or cGMP in a variety of sample types.

  • Sensitive ELISA with optional acetylation protocol increases sensitivity 10-fold (0.039 pmol/ml)
  • Regularly cited in peer-reviewed publications
  • Simple, efficient and well-established sample handling protocols


Measure cAMP, a Regulator of Melanin Synthesis

Graph demonstrates the robust and reproducible nature of the competitive cAMP ELISA kit (Prod. #ADI-900-067) showing standard curves from 10 lots manufactured over 6 years

 

L-(+)-Ascorbic acid


Vitamin C is known to induce collagen synthesis and provide protection against photodamage. It is also an excellent depigmentating agent because it inhibits the action of the enzyme tyrosinase by reducing o–quinones resulting in a decrease in melanin production. Purity: ≥97%

Ebselen


Recent findings suggest that ebselen functions as a depigmenting compound by inhibiting melanin synthesis and melanosome transfer to keratinocytes. Purity: ≥98% (NMR)

Trolox®


This cell permeable vitamin E derivative decreases postinflammatory hyperpigmentation after injury through anti-inflammatory action. Purity: ≥97%

 

cAMP complete ELISA kit 

Most sensitive (0.037 pmol/ml) and complete colorimetric kit for intra- and extracellular cAMP quantification.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-163 96 wells 411.00 USD
Do you need bulk/larger quantities?
 

Direct cAMP ELISA kit 

Most sensitive (0.037 pmol/ml) colorimetric kit for intracellular cAMP quantification.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-066 96 wells 378.00 USD
Do you need bulk/larger quantities?
 

cAMP ELISA kit 

Most sensitive (0.039 pmol/ml) colorimetric kit for extracellular cAMP quantification.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-067 96 wells 352.00 USD
Do you need bulk/larger quantities?
 

Catalase fluorometric detection kit 

Fluorescent detection, HTS | Print as PDF
 
ADI-907-027 500 tests 350.00 USD
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PKA kinase activity kit 

Non-radioactive protein kinase assay provides rapid and sensitive detection
Colorimetric detection, Activity assay | Print as PDF
 
ADI-EKS-390A 96 wells 519.00 USD
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RO-20-1724 

PDE inhibitor
29925-17-5, ≥99% (TLC) | Print as PDF
 
BML-EI117-0100 100 mg 117.00 USD
 
BML-EI117-1000 1 g 356.00 USD
Do you need bulk/larger quantities?
 

Rolipram 

PDE inhibitor
61413-54-5, ≥98% (TLC) | Print as PDF
 
BML-PD175-0010 10 mg 68.00 USD
 
BML-PD175-0050 50 mg 290.00 USD
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R-(-)-Rolipram 

PDE inhibitor
85416-75-7, ≥98% (HPLC) | Print as PDF
 
BML-PD177-0005 5 mg 170.00 USD
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SQ 20009 

PDE inhibitor
35838-58-5, ≥98% (HPLC) | Print as PDF
 
BML-PD130-0005 5 mg 63.00 USD
 
BML-PD130-0025 25 mg 264.00 USD
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S-(+)-Rolipram 

PDE inhibitor
85416-73-5, ≥98% (HPLC) | Print as PDF
 
BML-PD178-0005 5 mg Inquire for pricing
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Zardaverine 

PDE inhibitor
101975-10-4, ≥98% (HPLC) | Print as PDF
 
BML-PD195-0005 5 mg 86.00 USD
 
BML-PD195-0025 25 mg 372.00 USD
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PDE4A (catalytic domain) (human), (recombinant) 

Produced in E. coli. Active catalytic domain of phosphodiesterase 4A. | Print as PDF
 
BML-SE521-0020 20 µg 459.00 USD
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PDE4B2 (catalytic domain) (human), (recombinant) 

Produced in E. coli. Active catalytic domain of phosphodiesterase 4B2. | Print as PDF
 
BML-SE522-0020 20 µg 459.00 USD
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PDE4D (catalytic domain) (human), (recombinant) 

Produced in E. coli. Active catalytic domain of phosphodiesterase 4D. | Print as PDF
 
BML-SE523-0020 20 µg 459.00 USD
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For Research Use Only. Not for use in diagnostic procedures.
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