United States
Neurodegeneration & Neural Signaling
It is estimated the aging worldwide population will result in over 100 million sufferers of dementia by the year 2050, a postulate that continues to drive major research efforts in neurodegenerative diseases and the associated loss of cognitive function. Diseases such as Alzheimer’s (AD), Parkinson’s (PD), Huntington’s (HD), and Amyotrophic Lateral Sclerosis (ALS) are considered diseases of protein homeostasis (proteostasis), characterized by loss of specific neuronal populations, and the presence of inclusion bodies consisting of insoluble, unfolded proteins. Drug development programs for treatment of these diseases include modulators of key proteins and enzymes that regulate proper protein folding, modification, and clearance, seeking to reverse or prevent the accumulation of protein aggregates and toxic intermediates.
NEW! 24(S)-Hydroxycholesterol ELISA Kit
Measure a pivotal marker of cerebral cholesterol homeostasis and neurodegenerative disease in tissue culture media, cerebral spinal fluid and tissue homogenate samples without mass spec in just 2 hours.- Convenient – user-friendly alternative to mass spectrometry
- Sensitive – measure as little as 0.78 ng/ml of 24(S)-hydroxycholesterol
- Time Saving – results from up to 36 samples in duplicate in just 2 hours
- Specific – low cross-reactivity with structurally related molecules
- Easy-to-use – liquid color-coded reagents reduce errors
Neurodegenerative Markers
Alzheimer’s Disease
Tau & Phospho-Tau Antibodies
14-3-3 Proteins & Antibodies
β-amyloid Peptides & Antibodies
BACE enzymes & Inhibitors
Presenilin 1 & 2 mAbs
24(S) Hydroxycholesterol ELISA
Caspase-6
Parkinson’s Disease
α-synuclein Protein & Antibodies
Parkin (human) pAb
HSC70 Protein & Antibodies
Huntington’s Disease
Huntingtin pAb
Huntingtin Interacting
Protein (HIP) mAbs
ALS
SOD-1 Antibodies
Mito-ID Membrane
Potential Detection Kit
ROS/Superoxide & ROS/RNS Detection Kits
Spinal Muscular Atrophy (SMA)
SMN ELISA Kit
SMN Protein & Antibody
Altered Processes
Gene Expression & Copy Number
aCGH Labeling Kits
BioArray® Amplification & Labeling Systems
Epigenetics Compound Library
Fluor de Lys® HDAC & Sirtuin Assays
Protein Synthesis & Folding
Stressgen® HSP/Chaperone Products
HSP70/HSP40/HSP27/HSF-1 Antibodies & ELISAs
αB-crystallin Protein & Antibodies
Post-translational Modification
Mono- & Polyubiquitinylation Antibodies
In Vitro Ubiquitinylation & SUMOylation Kits
UbiQapture™-Q & SUMO Qapture-T® Kits
SUMO 1 & SUMO 2/3 Antibodies
Fluor de Lys® HDAC6 Drug Discovery Kit
Aggregate Clearance/Protein Degradation
ProteoStat® Aggresome Detection Kit
Cyto-ID® Autophagy Detection Kit
p62 (SQSTM1)/NBR1 ELISA Kits
Autophagy Compound Library
Lyso-ID® Red Detection Kit
Proteasome ELISA Kit
Oxidative Stress
Heme Oxygenase ELISAs & Antibodies
ROS/RNS Detection Kits
SOD Antibodies & Activity Assays
REDOX Compound Librar
Areas of Interest
Essential tools for analysis of protein folding, aggregate detection & clearance, and programmed cell death.
High-sensitivity assay kits for quantification of neurotransmitters, stress hormones, cyclic nucleotides, calcium mobilization, and more.
Ready-to-screen collections of neuromodulators, plus over 1500 stand-alone activators and inhibitors.
Over 500 thoroughly validated antibodies for neurodenerative markers, synaptic vesicle markers, GPCRs and more.
Relevant TechNotes
Sphingolipids: Breaking the Blood Brain Barrier
2013 April 19 | Tags:
Drug Discovery,
Neuroscience
Blocking Dkk-1 suppresses β-amyloid peptide-induced neuronal synapse loss in transgenic mouse models of Alzheimer’s disease.
2012 November 2 | Tags:
Neuroscience,
Screening
Harnessing the human body’s natural analgesic for pain relief.
2012 May 30 | Tags:
Neuroscience
Resveratrol's metabolic effects include inhibition of PDE 4 and activation of sirtuin 1.
2012 April 13 | Tags:
Cancer,
Epigenetics,
Inflammation,
Metabolism,
Neuroscience
Caspase-6: A Potential Therapeutic Target for Neurodegenerative Disease.
2012 March 28 | Tags:
Cancer,
Neuroscience
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Latest Literature
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10-Oct-12 |
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