TNF & TNF Receptor Superfamily

Since the identification of two distinct tumor-necrosis factors (TNFs a and b) in 1984, the TNF superfamily has grown to include 19 soluble and membrane-bound ligands and 32 receptors. Through timely expression and intricate signaling, TNF ligands and receptors act to regulate cell responses including activation, proliferation, differentiation, and apoptosis. While critical to regulation of beneficial processes such as immune defense and hematopoiesis, TNF signaling is also implicated in tumorigenesis, transplant rejection, virus replication, bone resorption, and diabetes, leading to the advent of numerous TNF –targeting therapeutics for cancer and auto-immune disease.

Figure adapted from Aggarwal BB. Nat Rev Immunol. 2003 Sep; 3(9): 745-56.

Enhanced TNF Ligands

Our high-activity MegaCD40L™ is the highest-purity, most stable on the market, and is just one of many reliable enhanced TNF ligands for immune activation studies.

NF-kB Signaling

Analyze expression, modification, and activation of NF-kB, the common transcription factor mediating TNF Superfamily signaling

Caspase Signaling

Enzyme activity assays, active enzymes, substrates, ELISA kits, and antibodies for key caspases.

Cell Death, Apoptosis, Autophagy

Browse our collection of over 1500 products for monitoring programmed cell death pathways.