Epigenetics

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Browse our complete Epigenetics range

Comprehensive Tools for Epigenetic Modification

Unravel the Code Within the Code

Epigenetics can be defined as the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states. A variety of chromatin-altering post-translational modifications (PTMs) to histone proteins including acetylation, methylation, and ubiquitinylation, as well as direct modifications to DNA, are known to turn gene transcription off or on. To date, acetylation/deacetylation of histone lysine residues, and methylation of DNA have proven to be of greatest clinical significance amongst epigenetic PTMs.

The approval of anti-cancer drugs such as Vorinostat and Decitabine, targeting Histone Deacetylases (HDACs) and DNA Methyltransferases (DNMTs), respectively, as well as pharma development pipelines targeting PTM regulating enzymes, are evidence that reprograming gene expression on an epigenetic level holds great clinical promise.

Related Research Areas

DNA Modifications

Histone Post-translational Modifications

5-hmC DNA Methylation
BIOARRAY® 5-hmC Methylation Kit
5-Hydroxymethylcytosine DNA ELISA Kit

5-mC DNA Methylation
DNMT Colorimetric Drug Discovery Kit
Express DNA Methylation Kit
Blood & Tissue DNA Methylation Kit
BIOARRAY® Methylated DNA IP Kit
5-Methylcytosine DNA ELISA Kit

Demethylation
LSD1 Fluorometric Drug Discovery Kit
LSD1 Active Enzyme

Acetylation
Acetyltransferase Activity Assays
p300/CBP Inhibitors, Activators, and Antibodies

Ubiquitinylation
UBIQAPTURE-Q® Kit
In Vitro Ubiquitinylation Kit
Mono- & Polyubiquitinylation Antibodies

Phosphorylation
Phospho-specific Histone Antibodies
Aurora Kinase Active Enzymes & Inhibitors

SUMOylation
SUMO & PolySUMO-QAPTURE® Kits
SUMO-QAPTURE-T® Kits
In Vitro SUMOylation Kit
SUMO 1 & SUMO 2/3 Antibodies

Deacetylation
FLUOR DE LYS® HDAC & Sirtuin Assays
CHEMILUM DE LYS® HDAC & Sirtuin Assays
COLOR DE LYS® HDAC & Sirtuin Assay
HDAC Antibodies
Resveratrol
Tubacin

Methylation
Methyltransferase Activity Assays
CARM1, PRMT, and SET7/9 Active Enzymes
Mono- & Tri-methyl-specific Histone Antibodies
Sinefungin

Complete Toolbox for Epigenetics Research

Isolate

Modify

Detect

EPIXTRACT® Total Histone Extract Kits
EPIXTRACT® DNA Isolation Kits
EPIXTRACT® Nuclear Protein Isolation Kits
UBIQAPTURE-Q® kit
SUMO-QAPTURE-T® kit
PolySUMO-QAPTURE® Kit
BIOARRAY® methylated DNA IP Kit

Ubiquitinylation Kit
Auto-ubiquitinylation kit
Ubiquitin conjugating kit (HeLa lysate-based)
Ubiquitin activating kit
SUMOylation Kit
NEDDylation Kit
Express DNA Methylation Kits
BIOARRAY® Methylation Kits

FLUOR DE LYS, COLOR DE LYS, CHEMILUM DE LYS
HDAC Assays
Methyltransferase Activity Kits
Acetyltransferase Activity Kits
ELISAs for 5-mC and 5-hmC methylation
DNMT Colorimetric Drug Discovery Kit
Antibodies for Epigenetic Modifications

Sample Extraction Kits

Rapid Extraction Kits for Epigenetic Workflows

Guarantee reproducible, high-yield isolation of histones, nuclear proteins and DNA

Rapid, reliable methods to isolate samples to for downstream applications.
Available in different formats with additional features to fit application.

Histone Post-translational Modifications

Solutions For Screening Epigenetic Regulators

For over a decade, the FLUOR DE LYS® deacetylase assay platform has freed researchers from cumbersome protocols for screening HDAC & Sirtuin activity. Our high-quality chemiluminescent, fluorescent, and colorimetric assays deliver more high-quality hits, and are backed by a broad panel of characterized inhibitors and PTM-specific antibodies for ubiquitinylation, sumoylation, methylation, acetylation, and phosphorylation.

Active Enzymes & Drug Discovery Assays

Convenient screening formats, featuring Fluor de Lys HDAC & Sirtuin assays, transferase & demethylase assays, and high-activity enzymes.

Small Molecules & Compound Libraries

Benchmark against known epigenetic modulators.

PTM-specific Antibodies

Detect acetylation, methylation, ubiquitinylation and more with high-quality antibodies backed by our Worry-Free program.

Ubiquitin & Ubl Signaling

Browse our industry-leading portfolio of active enzymes, antibodies, and kits for ubiquitinylation and SUMOylation.

DNA Modifications

Convenient Kits for Sample Conversion and Detection

DNA methylation can alter gene expression, cell differentiation and often results in unidirectional changes to genomic DNA. Its involvement in so many cellular processes means errors resulting in abnormal DNA methylation patterns can lead to disease. Expanding our expertise in epigenetic modification analysis, Enzo Life Sciences now offers a portfolio of products that enable detection of DNA methylation.