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Immuno-Oncology

Innovative Solutions for Immuno-Oncology Research

Understanding Immune Checkpoints in Immunology and Cancer

At Enzo, we offer a complete set of solutions for immuno-oncology research including antibodies, ELISA kits, and recombinant proteins. Our diverse scientific and technical expertise has helped us create innovative assays and reagents to help support immuno-oncology research. We provide flexible and validated tools to help you generate reliable and consistent results.



 

Accelerate Your Immune Activation Studies

Key Toll-like Receptor Ligands

TLRs play a role in the innate immune system, detecting pathogen-associated molecule patterns (PAMPs) of bacterial, viral, fungal, and protozoal origin.


 

Co-Stimulation of T Cell Response

Superior Performance from Carefully Engineered TNF Superfamily Ligands MEGACD40L® Protein (soluble) (human), (recombinant)

TLRs play a role in the innate immune system, detecting pathogen-associated molecule patterns (PAMPs) of bacterial, viral, fungal, and protozoal origin.

  • Superior Performance from Carefully Engineered TNF Superfamily Ligands
  • MEGACD40L® Protein (soluble) (human), (recombinant)


B cell lymphocyte activation by various CD40L constructs. PBMCs were treated for 48 hrs in media containing serially diluted CD40L, CD40L + 2 μg/mL Enhancer, or MEGACD40L® Protein. Cells were dual-stained with α-human CD19–PE and α-human CD86–APC and analyzed by flow cytometry.
Data are presented as the percent of CD19+ B cells that co-stain as CD86+.
 

Death Receptor Ligands

Members of the tumor necrosis factor (TNF) receptor gene superfamily bind to extrinsic ligands and transduce intracellular signals leading to the destruction of the cell. Ligands, such as FasL and TNF-α, hold potential as targets for therapeutic and diagnostic applications.

 

SUPERFASLIGAND® Protein (soluble)(human), (recombinant)

  • Features an N-Terminus linker shown to improve stability
  • Enhanced immune activation compared to other recombinant ligands
  • Mimics glycosylation of native human FasL
Induction of Cell Death with SUPERFASLIGAND® Protein



Jurkat cells were incubated with the indicated concentration of SuperFasL and cell proliferation was assayed. % Viability was determined in comparison to control wells with no SuperFasL.
 

Quantify Biomarkers Of Inflammation With ELISA Kits

High-Specificity ELISAs for Innate and Adaptive Immune Research

Enzo offers a large variety of immunoassay kits in both immunometric and competitive assay formats. As scientists and manufacturers of kits, we understand the critical nature of your research. Each kit is put through rigorous testing to ensure high precision, accuracy, sensitivity, and specificity. You can be confident that you will obtain reproducible results, day-after-day, and lot-after-lot.

  • Sensitivity – detect even the lowest sample concentration
  • Broad Range – minimize need for dilution
  • Consistent – strict quality control guidelines ensure reproducible results, lot-after-lot
  • Trusted – reliability highlighted in peer-reviewed publications for three decades
  • Flexible – wide range of sample types
Highly Sensitive Measurement of IL-6



A typical standard curve for IL-6 (human) High Sensitivity ELISA kit
 

Immune Checkpoints

Highly specific antibodies validated for various applications, from flow cytometry to IHC, to help you discover immune checkpoint inhibitors, develop novel immunotherapies, and support your immuno-oncology research.

 

LAG-3 (human) mAb




IHC using anti-LAG-3 [17B4] on human tonsil tissue.
 

High Quality Antibodies Deliver Superior Results

Detect Specific Cell Populations with Antibodies for CD Markers

Enzo offers over 50 CD antibodies validated for flow cytometry and microscopy applications.

 
CD Marker T Cells B Cells Dendritic Cells NK Cells Stem Cell
Precursors
Macrophages Granulocytes Endothelial
Cells
Epithetial
Cells
CD3 Find
CD4 Find Find Find
CD8 Find Find
CD9 Find Find Find Find Find Find
CD11a Find Find Find Find Find
CD18 Find Find Find Find Find Find
CD20 Find Find
CD23 Find Find Find Find Find Find
CD26 Find Find Find Find Find
CD28 Find
CD31 Find Find Find Find Find Find
CD36 Find Find Find Find
CD38 Find Find Find Find Find Find
CD39 Find Find Find Find Find Find Find
CD40 Find Find Find Find Find Find Find Find
CD40L Find
CD41 Find
CD41a Find
CD41b Find
CD42 Find
CD44 Find Find Find Find Find Find Find
CD45 Find Find Find Find Find Find Find
CD45RA Find Find Find Find Find Find
CD49b/CD29 Find Find Find Find Find Find Find Find Find
CD49f Find Find Find Find Find
CD51 Find Find
CD52 Find Find Find Find
CD54 Find Find Find Find
CD66a Find Find
CD66b Find
CD66c Find Find
CD66e Find
CD68 Find Find Find Find Find Find
CD74 Find Find Find Find Find Find
CD80 Find Find Find Find
CD83 Find Find
CD87 Find Find Find Find Find
CD107b Find Find Find
CD123 Find Find Find Find
CD127 Find Find Find
CD134 Find
CD137 Find Find Find
CD163 Find
CD194 Find Find Find Find Find
CD205 Find Find Find
CD207 Find
CD208 Find
CD223 Find Find Find
CD243 Find
CD279 Find
CD324 (E-cadherin) Find Find
CD325 Find

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For Research Use Only. Not for use in diagnostic procedures.
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