4α-Phorbol 12,13-didecanoate

TRPV4 agonist



BML-PE147-0001	1 mg	108.00 USD

BML-PE147-0005	5 mg	433.00 USD

Replaces Prod. #: ALX-445-006

Negative control for phorbol 12,13-didecanoate. Activates TRPV4 (EC₅₀ 200-400nM)

Product Specification

Alternative Name:	4αPDD

Formula:	C₄₀H₆₄O₈

MW:	672.9

Purity:	≥ 99%

Appearance:	Colorless oil

CAS:	27536-56-7

Solubility:	Soluble in DMSO (25mg/ml), methanol, 100% ethanol, acetone, ether or dimethyl formamide.

Long Term Storage:	-20°C

Use/Stability:	Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of orgnic solvent to vial to prepare concentrated stock solution. Interemtiate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media.Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Hazard:	HIGHLY IRRITANT. HIGHLY PYROGENIC. MAY BE CARCINOGENIC. VERY TOXIC.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Functional Characterisation of Transient Receptor Potential Channels in Mouse Urothelial Cells: W. Everaerts, et al.; Am. J. Physiol. Renal Physiol. in press, (2009), Abstract;

Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study: T.K. Klausen, et al.; J. Med. Chem. 52, 2933 (2009), Abstract; Full Text

The vallinoid transient receptor potential channel Trpv4: From structure to disease: W. Everaerts, et al.; Prog. Biophys. Mol. Biol. in press, (2009), Abstract;

TRPV4 calcium entry channel: a paradigm for gating diversity: B. Nilius et al.; Am J Physiol Cell Physiol 286, C195 (2004), Abstract;

Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives: H. Watanabe et al.; J Biol Chem 277, 13569 (2002), Abstract;

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters: M. Castagna et al.; J. Biol. Chem. 257, 7847 (1982), Abstract;