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4α-Phorbol 12,13-didecanoate

[4αPDD]
 
BML-PE147-0001 1 mg 105.00 USD
 
BML-PE147-0005 5 mg 420.00 USD
 
Replaces Prod. #: ALX-445-006

Negative control for phorbol 12,13-didecanoate. Activates TRPV4 (EC50 200-400nM)

Product Specification

Formula:C40H64O8
 
MW:672.9
 
Purity:≥ 99%
 
Appearance:Colorless oil
 
CAS:27536-56-7
 
Solubility:Soluble in DMSO (25mg/ml), methanol, 100% ethanol, acetone, ether or dimethyl formamide.
 
Shipping:AMBIENT
 
Long Term Storage:-20°C
 
Use/Stability:

Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of orgnic solvent to vial to prepare concentrated stock solution. Interemtiate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media.Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

 
Hazard:HIGHLY IRRITANT.
HIGHLY PYROGENIC.
MAY BE CARCINOGENIC.
VERY TOXIC.
 
Background / Technical Information:Please click here for the comprehensive product datasheet.
 
445-006
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445-006

Product Literature References

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters: M. Castagna et al.; J. Biol. Chem. 257, 7847 (1982), Abstract;
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives: H. Watanabe et al.; J Biol Chem 277, 13569 (2002), Abstract;
TRPV4 calcium entry channel: a paradigm for gating diversity: B. Nilius et al.; Am J Physiol Cell Physiol 286, C195 (2004), Abstract;
Functional Characterisation of Transient Receptor Potential Channels in Mouse Urothelial Cells: W. Everaerts, et al.; Am. J. Physiol. Renal Physiol. in press, (2009), Abstract;
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study: T.K. Klausen, et al.; J. Med. Chem. 52, 2933 (2009), Abstract; Full Text
The vallinoid transient receptor potential channel Trpv4: From structure to disease: W. Everaerts, et al.; Prog. Biophys. Mol. Biol. in press, (2009), Abstract;
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