Int-H1-S6A F8 c-myc inhibitor

c-Myc inhibitor



BML-P605-0500	0.5 mg	143.00 USD

H1 DNA-binding region of c-Myc containing Ser to Ala, and Phe to Ala substitutions (underlined) to confer an increase in its potency to inhibit c-Myc. The N-terminus of this peptide is the Int peptide sequence derived from the third Antennapedia homeodomain, to confer cell permeability. Control for this peptide is H1-S6A,F8A c-Myc inhibibitor peptide (Prod. No. BML-P606). Inhibited cloning efficiency of MCF-7 human breast cancer cells by 90% at 10 µM (IC₅₀=5.9 µM). In MCF-7 cells, it inhibited cell growth and induced apoptosis.

MW:	3873.6

Purity:	≥95% (HPLC)

Sequence:	Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asn-Glu-Leu-Lys-Arg-Ala-Phe-Ala-Ala-Leu-Arg-Asp-Gln-Ile

Formulation:	Lyophilized solid

Solubility:	Soluble in water

Long Term Storage:	-20°C

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Product Literature References

Inhibition of cancer cell growth and c-Myc transcriptional activity by a c-Myc helix 1-type peptide fused to an internalization sequence: L. Giorello et al.; Cancer. Res. 58, 3654 (1998), Abstract;

The third helix of the Antennapedia homeodomain translocates through biological membranes: D Derossi et al.; J. Biol. Chem. 270, 14255 (1995), Abstract;

Interaction of the bHLH-zip domain of c-Myc with H1-type peptides. Characterization of helicity in the H1 peptides by NMR: L. J. Draeger et al.; 269, 1785 (1994), Abstract;