Mca-RPPGFSAFK(Dnp)

Protease substrate



BML-P227-0001	1 mg	130.00 USD

Fluorogenic substrate for ECE-1 and ECE-2, ACE1 and ACE2, neprilysin, MMP-2 and MMP-9, thimet oligopeptidase, as well as cathepsin A, cathepsin X/Z, BACE, and insulinase, but not MMP-1.Mca fluorescence is quenched by the Dnp group until cleavage separates them. Ex.: 328nm, Em.: 393nm, although the following Ex/Em have also been used: 320-340/400-420. This substrate is useful for inhibitor screening and kinetic analysis.

Product Specification

MW:	1388.5

Purity:	98%

Sequence:	Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH[Mca=(7-methoxycoumarin-4-yl)acetyl;Dnp=2,4-dinitrophenyl]

Long Term Storage:	-20°C

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Product Literature References

Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors: N. Jullien, et al.; J. Med. Chem. 53, 208 (2010), Abstract;