Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. DMNQ does not react with free thiol groups, is non-alkylating and adduct-forming in contrast to other quinones. Thus, DMNQ is a valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis.
Product Details
| Alternative Name: | 2,3-Dimethoxy-1,4-naphthoquinone |
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| Formula: | C12H10O4 |
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| MW: | 218.2 |
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| CAS: | 6956-96-3 |
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| Purity: | ≥99% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Yellow crystalline solid. |
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| Solubility: | Soluble in acetone, DMSO or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells: J.M. Dypbukt, et al.; J. Biol. Chem.
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