Dimethylargininase-1, pAb

[Dimethylarginine dimethylaminohydrolase 1, DDAH-1]



ALX-215-066-R100	100 µl	290.00 USD

Product Specification

Formulation:	Liquid. Neat serum.

Immunogen:	Full lenght bovine dimethylargininase 1 (DDAH-1).

Source/Host:	From rabbit.

Specificity:	Recognizes human, mouse, bovine and porcine dimethylargininase-1. Detects a band of ~35kDa by Western blot. Does not cross-react with DDAH-2.

Application:	Western Blot (1:5’000) Optimal conditions must be determined individually for each application.

Shipping:	SHIPPED ON DRY ICE

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Miscellaneous/General:	Dimethylargininase (DDAH) is a Cys-hydrolase, which, through catabolism of mono- and dimethylated derivatives of L-arginine, regulates the activity of nitric oxide synthase. DDAH-1 is mainly present in tissues expressing the constitutive forms of nitric oxide synthase such as brain and kidney.

Product Literature References

Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease: M.A. Smith, et al.; Free Radic. Biol. Med. 25, 898 (1998), Abstract;

Toward the Development of Inhibitors Directed against Mammalian DDAH Proteins: Considerations from Homology Modeling of DDAH-2 and DDAH Activity Tracing in Tissue Homogenate: M. Knipp; Lett. Drug Des. Discov. 4, 570 (2007), Abstract;