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BMP-4 (human), (recombinant)

 
ENZ-PRT259-0020 20 µg 880.00 USD
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Product Specification

Alternative Name:Bone morphogenetic protein 4
 
MW:Dimer, 13.1/26.2 kDa (116/232 amino acids).
 
Source:Produced in genetically modified CHO cells.
 
UniProt ID:P12644
 
Formulation:Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:≤ 1 EU/µg
 
Reconstitution:Reconstitute in sterile water at 0.1 mg/mL.
 
Shipping:Ambient
 
Long Term Storage:-80°C
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution.
 
Scientific Background:Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic growth factor family (BMP) and functions as a critical component in the culture and differentiation of stem cells. Active BMP-4 forms a homodimer or a heterodimer with related BMPs. BMP-4 is integral for the differentiation of mesoderm and ectoderm from pluripotent stem cells (iPSCs and ESCs) in stem cell cultures. BMP-4 is also used in culturing cardiomyocytes, early hematopoietic cells, hepatocytes, bone, cartilage, adipocytes, and lung cells, as well as inhibiting early neuronal differentiation.
 
ENZ-PRT259-chart
Figure 1. Human BMP-4 induced alkaline phosphatase activity in ATDC-5 cells.
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ENZ-PRT259-chart

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