Product Details
| Alternative Name: | Bone morphogenetic protein 4 |
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| MW: | Dimer, 13.1/26.2 kDa (116/232 amino acids). |
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| Source: | Produced in genetically modified CHO cells. |
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| UniProt ID: | P12644 |
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| Formulation: | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | ≤ 1 EU/µg |
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| Reconstitution: | Reconstitute in sterile water at 0.1 mg/mL. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic growth factor family (BMP) and functions as a critical component in the culture and differentiation of stem cells. Active BMP-4 forms a homodimer or a heterodimer with related BMPs. BMP-4 is integral for the differentiation of mesoderm and ectoderm from pluripotent stem cells (iPSCs and ESCs) in stem cell cultures. BMP-4 is also used in culturing cardiomyocytes, early hematopoietic cells, hepatocytes, bone, cartilage, adipocytes, and lung cells, as well as inhibiting early neuronal differentiation. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure 1. Human BMP-4 induced alkaline phosphatase activity in ATDC-5 cells.
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Product Literature References
Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders: N. Darbinian, et al.; Int. J. Mol. Sci.
24, 135 (2023),
Abstract;
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