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IL-21 (mouse), (recombinant)

 
ENZ-PRT249-0010 10 µg 260.00 USD
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Product Specification

Alternative Name:Interleukin-21
 
MW:~15.1 kDa
 
Source:Produced in E. coli. Contains 130 amino acids.
 
UniProt ID:Q9ES17
 
Formulation:Lyophilized from a sterile (0.2 micron) filtered solution containing 20 mM sodium bicarbonate, pH 8.5.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:≤1 EU/µg protein (LAL test)
 
Biological Activity:Mouse thymocyte proliferation with costimulation; ED50 ≤ 10 ng/mL (≥ 1.0 x 105 units/mg).
 
Reconstitution:Reconstitute in sterile water at 0.1 mg/mL.
 
Shipping:Ambient
 
Long Term Storage:-80°C
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution.
 
Scientific Background:Interleukin 21 (IL-21) is normally expressed by activated CD4+ T cells. The IL-21 receptor activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. IL-21 cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.
 

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