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IL-17A (mouse), (recombinant)

 
ENZ-PRT244-0025 25 µg 260.00 USD
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Product Specification

Alternative Name:Interleukin-17A, IL-17, CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8
 
MW:Dimer, ~15.1/30.2 kDa
 
Source:Produced in E. coli. Contains 134/268 amino acids.
 
UniProt ID:Q62386
 
Formulation:Lyophilized from a sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA).
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:≤1 EU/µg protein (LAL test)
 
Biological Activity:Production of IL-6 by mouse 3T3 cells; ED50≤5 ng/mL (≥2.0x105 units/mg).
 
Reconstitution:Reconstitute in sterile water at 0.1 mg/mL.
 
Shipping:Ambient
 
Long Term Storage:-80°C
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution.
 
Scientific Background:Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a pro-inflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. Cytokines and chemokines then mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites. Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis.
 

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