| Alternative Name: | Fibroblast growth factor 10, Keratinocyte growth factor 2 |
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| MW: | ~19.3 kDa |
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| Source: | Produced in E. coli. Contains 170 amino acids. |
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| UniProt ID: | O15520 |
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| Formulation: | Lyophilized from a sterile (0.2 micron) filtered solution containing 10 mM sodium phosphate, pH 7.5. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | ≤1 EU/µg protein (LAL test) |
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| Biological Activity: | 4MBr-5 cell proliferation; ED50 ≤ 200 ng/mL (≥ 5.0 x 103 units/mg). |
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| Reconstitution: | Reconstitute in sterile water at 0.1 mg/mL. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | Fibroblast growth factor 10 (FGF-10) is important during embryonic development, especially during kidney, lung, limb, brain,and heart morphogenesis. FGF-10 is expressed in mesenchymal cells and facilitates epithelial-mesenchymal signaling through binding to the FGF receptor 2b (FGFR2b). FGF-10 induces the migration and invasion of cancer cells. |
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| Regulatory Status: | RUO - Research Use Only |
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