Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Insulin receptor (human), (recombinant) (His-tag) (GST-tag)

 
ENZ-PRT207-0020 20 µg 396.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:CD220, HHF5, INSR
 
MW:72.3 KDa
 
Source:Produced in insect cells using Baculovirus expression system. The cytoplasmic domain of the human insulin receptor (aa 989-1382) is fused with an N-terminal polyhistidine-tagged GST tag at the N-terminus.
 
UniProt ID:P06213
 
Formulation:Liquid. In 50 mM Tris, pH 7.4, containing 100 mM NaCl, 0.3 mM DTT and 20% glycerol.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<1.0 EU/μg purified protein (LAL test).
 
Application Notes:Useful for enzyme kinetics and inhibition studies and for phosphoylation of target substrates.
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-80°C
 
Handling: Avoid freeze/thaw cycles. Prepare aliquots for optimal storage.
 
Scientific Background:INSR (Insulin receptor) (CD220), is a transmembrane receptor activated by insulin. INSR exists as a tetramer consisting of two alpha and two beta subunits linked by disulfide bonds. INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). INSR is expressed in the peripheral nerve, fibroblasts, kidney, liver, skin and striated muscle. Defects in INSR are associated with insulin resistance, Donohue syndrome, noninsulin-dependent diabetes mellitus, and Rabson-Mendenhall syndrome.
 

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Insulin receptor
By biological activity:
Insulin receptor Recombinant protein
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Catalogs
Diabetes Catalog
Diabetes Catalog
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,