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Angiopoietin-2 (human), (recombinant)

 
ENZ-PRT162-0010 10 µg 214.00 USD
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Product Specification

Alternative Name:ANGPT2, AGPT2, ANG2
 
MW:~50.1 kDa
 
Source:Produced in HEK 293 cells.
 
UniProt ID:O15123
 
Formulation:Lyophilized from 0.22µm filtered solution in PBS, pH 7.4. Generally 5-8% mannitol or trehalose is added as a protectant before lyophilization.
 
Purity:≥90% (SDS-PAGE)
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Scientific Background:ANGPT2 binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. ANGPT2 can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers (i.e. VEGF), ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, serving as a permissive angiogenic signal.
 

Product Literature References

IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis: S. Jiang, et al.; Cell. Physiol. Biochem. 40, 1105 (2016), Abstract;

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