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NEDD8 activating enzyme E1 (human), (recombinant) (His-tag)

 
ENZ-PRT112-0050 50 µg 194.00 USD
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Product Specification

Alternative Name:NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3
 
MW:62kDa + 53kDa (heterodimer: 112.15kDa)
 
Source:Produced in E. coli.
 
EC:6.3.2.-
 
UniProt ID:Q8TBC4
 
Formulation:Liquid. In 25mM HEPES, pH 7.5, containing 150mM NaCl, 1mM DTT.
 
Purity:≥95% (SDS-PAGE)
 
Purity Detail:Copurified in His-tagged form with Uba3; copurified with APP-BP1.
 
Application Notes:For use in NEDD8 conjugation reactions and NEDDylation pathway studies.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Conjugation of mature NEDD8 to specific lysine residues on target proteins via isopeptide bonds allows NEDD8 to play a critical regulatory role in cell proliferation and development, a process closely associated to the ubiquitin-proteasome pathway. An increasing number of substrates for NEDDylation are being identified including the tumor suppressors p53 and VHL and members of the well-characterized cullin ubiquitin E3 ligase family, underlining the vital role NEDD8 modification plays in cellular processes.
 
ENZ-PRT112 SDS-PAGE
SDS-PAGE Analysis. Lane 1: MW Marker; Lane 2: 1 ug NEDD8 E1.
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ENZ-PRT112 SDS-PAGE

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