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Exendin-4

GLP-1 receptor agonist
 
ENZ-PRT111-0500 500 µg 102.00 USD
 
ENZ-PRT111-0001 1 mg 163.00 USD
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Exendin-4 is a 39 aa polypeptide and incretin mimetic which was first isolated from Gila monster saliva. The synthetic form, Exenatide, is a glucagon like peptide-1 (GLP-1) agonist approved for the treatment of diabetes mellitus type II. Research shows Exendin-4 is involved in glucose-dependent enhancement of insulin secretion, reduction of hyperglycemia, glucose-dependent suppression of inappropriately high glucagon secretion, slowing of gastric emptying, and reduction of food intake, often with body weight reduction or blunting of weight gain.

Product Specification

Alternative Name:Exenatide
 
Sequence:His-Gly-Glu-Gly-Thr-Phe-T​hr-Ser-Asp-Leu-Ser-Lys-Gl​n-Met-Glu-Glu-Glu-Ala-Val​-Arg-Leu-Phe-Ile-Glu-Trp-​Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pr​o-Ser-NH2
 
MW:4186.57
 
Source:Synthetic.
 
CAS:141758-74-9
 
Formulation:Lyophilized.
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

Evolution of Exenatide as a Diabetes Therapeutic: S. Bhavsar, et al.; Curr. Diabetes Rev. 9, 161 (2013), Abstract; Full Text
The role of GLP-1 mimetics and basal insulin analogues in type 2 diabetes mellitus: guidance from studies of liraglutide: A. H. Barnett, et al.; Diabetes Obes Metab. 14, 304 (2011), Abstract; Full Text

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