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PLAQPRO® Lp-PLA2 Assay

Enzyme activity kit to measure Lp-PLA2 activity in  serum samples
 
ENZ-KIT179-0200 200 tests Inquire for pricing
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  • Cost-efficient alternative to competitor's Lp-PLA2 detection system
  • Wide analytical measurement range from 0 - 400.0 nmol/min/mL
  • Analytical sensitivity of 0.236 nmol/min/mL
  • High specificity and reproducibility, lot-after-lot
  • Ready-to-use calibration standards and QC controls are provided
  • Designed to run on automated clinical chemistry analyzers
The PLAQPRO® Lp-PLA2 Assay measures the enzyme activity of Lp-PLA2 (lipoprotein-associated phospholipase A2) in serum samples. The assay is designed to run on automated clinical chemistry analyzers.
ENZ-KIT179 kit
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ENZ-KIT179 kit

Product Specification

Sensitivity:0.236 nmol/min/mL
 
Applications:Colorimetric detection, HTS
 
Application Notes:For the measurement of enzyme activity of Lp-PLA2 (lipoprotein-associated phospholipase A2) in serum samples.
 
Species reactivity:Human
 
Kit/Set Contains:Lp-PLA2 assay buffer
Lp-PLA2 assay substrate
5 calibrator standards
QC low control
QC high control
 
Scientific Background:Approximately two-thirds of heart attacks and strokes are caused by the rupture of an unstable, rupture-prone atherosclerotic plaque. Unstable plaques are characterized by high levels of inflammatory cells and inflammatory mediators.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is produced by inflammatory cells and circulates primarily bound to low-density lipoprotein (LDL) and is to a lesser extent associated with high-density lipoprotein (HDL) in human plasma. LDL oxidation is an early key event in the pathogenesis of atherosclerosis. Elevated Lp-PLA2 levels have been found in atherosclerotic plaques and rupture lesions.
 
Technical Info/Product Notes:The PLAQPRO® Lp-PLA2 Assay is a colorimetric readout enzyme activity assay. During the test, Lp-PLA2  in serum samples hydrolyze the SN2 position of the substrate, 1-myristoyl-2-(4-nitrophenylsuccinyl)phosphatidylcholine. The resulting colored reaction product, 4-nitrophenol, is measured spectrophotometrically and the rate of formation of 4-nitrophenol is determined over successive measurements.

The assay kit includes five Lp-PLA2 calibrator standards for use in generating a standard curve fit of change in absorbance versus Lp-PLA2 activity level in nmol/min/mL. The activity of Lp-PLAin serum samples is interpolated from the calibration curve.
 
UniProt ID:Q13093
 

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Sensitive, Accurate Detection of Lp-PLA2 Activity
Sensitive, Accurate Detection of Lp-PLA2 Activity
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