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BIOLIKE® Rituximab conformational ELISA kit

Systematic and sensitive immunoassay to compare the structural conformation between Rituximab and a biosimilar mAb.
 
ENZ-KIT125-0003 3x96 wells 964.00 USD
Do you need bulk/larger quantities?
 
  • Unique measurement of biosimilar mAb Higher Order Structure (HOS) comparability
  • High throughput format with results in 3 hours
  • Correlates well with bioassays and glycosylation analysis
The BIOLIKE® Rituximab conformational ELISA kit is a systematic and sensitive immunoassay that uses a panel of more than 30 antibodies to measure the structural conformation of Rituximab to enable a Higher Order Structure (HOS) comparison to a biosimilar mAb.
ENZ-KIT125 Fig1
A typical ELISA , with only the Rituximab reference protein, in the variable region
ENZ-KIT125 Fig2
A typical ELISA , with only the Rituximab reference protein, in the constant region
Please mouse over
ENZ-KIT125 Fig1 ENZ-KIT125 Fig2

Product Specification

Assay Time:3 hours
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the systematic 3-D conformational comparability analysis of a biosimilar to Rituximab.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Kit/Set Contains:3 x 96 well plates, 5x dilution buffer, 10x PBS-T, reporting antibody, streptavidin-HRP conjugate, TMB substrate, stop solution, plate sealer
 
Scientific Background:Rituximab is a chimeric monoclonal antibody that targets CD20, a cell-surface receptor on B-cells. It is used for the treatment of lymphomas, leukemia’s and autoimmune diseases that are characterized by an overabundance of B-cells. This kit will allow for conformational comparison between biosimilars and authentic Rituximab.
 
Technical Info/Product Notes:Biologic comparability is essential to the successful development process of biosimilars; the 3-D conformation of a protein is an important factor in its biological function. Due to their large size and rotational characteristic, proteins generally exhibit complex 3-D conformations.

Enzo Life Sciences' line of BIOLIKE® conformational ELISA kits provide a sensitive, systematic, and robust measurement of biosimilar conformation comparability at the molecular level. The BIOLIKE® conformational ELISA kit allows for HOS characterization between biosimilars and marketed mAbs.
 

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