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R428

Selective inhibitor of AXL
 
ENZ-CHM205-0001 1 mg 224.00 USD
 
ENZ-CHM205-0005 5 mg 632.00 USD
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R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. R428 inhibits AXL at low nanomolar values and blocks AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Reported IC50 values are 11-14nM .

Product Specification

Alternative Name:1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(S)-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine
 
Formula:C30H34N8
 
MW:506.6
 
CAS:1037624-75-1
 
Purity:≥98% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO (60mg/ml) or ethanol (1mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
ENZ-CHM205 structure
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ENZ-CHM205 structure

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