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Baricitinib phosphate

Selective JAK1 and JAK2 inhibitor
 
ENZ-CHM198-0001 1 mg 128.00 USD
 
ENZ-CHM198-0005 5 mg 240.00 USD
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Baricitinib is a selective JAK1 and JAK2 inhibitor. IC50 values are 5.9nm for JAK1, and 5.7nM for JAK2. In cell based assays Baricitinib/INCB-28050 demonstrated inhibition of intracellular signaling of multiple pro-inflammatory cytokines including IL-6 and IL-23 at concentrations of < 50 nM, and also showed good efficacy in a number of animal models at doses of 10mg/kg and below. Baricitinib is in Phase III development as a potential treatment for rheumatoid arthritis. It is in Phase II development as a potential treatment for psoriasis and diabetic nephropathy.

Product Specification

Alternative Name:INCB028050, LY3009104, 2-[1-Ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
 
Formula:C16H17N7O2S . H3PO4
 
MW:469.4
 
CAS:1187595-84-1
 
Purity:≥99% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:White powder.
 
Solubility:Soluble in DMSO (74mg/ml) or ethanol (1mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
ENZ-CHM198 structure
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ENZ-CHM198 structure

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