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Tivozanib

Potent inhibitor of VEGFRs
 
ENZ-CHM195-0001 1 mg 56.00 USD
 
ENZ-CHM195-0005 5 mg 117.00 USD
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Tivozanib is a potent inhibitor of VEGFR-1, 2 and 3 (IC50 = 0.21, 0.16 and 0.24 nM respectively). Promising anticancer agent in several different tumor types, including breast, lung and colorectal.

Product Specification

Alternative Name:AV-951, KRN-951
 
Formula:C22H19ClN4O5
 
MW:454.9
 
CAS:475108-18-0
 
Purity:≥95% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:White powder.
 
Solubility:Soluble in DMSO (20mg/ml) or ethanol (<1mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:VEGF receptors are receptors for vascular endothelial growth factor. There are three main subtypes of VEGFR, numbered 1, 2 and 3. Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).
 
ENZ-CHM195 structure
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ENZ-CHM195 structure

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