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BX795

Inhibitor of PDK1, TBK1, IKK-ε, IRF3
 
ENZ-CHM189-0005 5 mg 63.00 USD
 
ENZ-CHM189-0010 10 mg 122.00 USD
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BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC50 = 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-ε. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC50 values ranging from submicromolar amounts (0.368 µM to greater than 450 µM).

Product Specification

Alternative Name:N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
 
Formula:C23H26IN7O2S
 
MW:591.5
 
CAS:702675-74-9
 
Purity:≥97% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:White powder.
 
Solubility:Soluble in DMSO (118mg/ml) or ethanol (1mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
ENZ-CHM189 structure
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ENZ-CHM189 structure

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For Research Use Only. Not for use in diagnostic procedures.
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