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CYC116

Aurora kinases A/B and VEGFR2 inhibitor and antitumor agent
 
ENZ-CHM171-0001 1 mg 56.00 USD
 
ENZ-CHM171-0010 10 mg 80.00 USD
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CYC116 is an orally active small molecule multi-kinase inhibitor with anti-neoplastic activity. CYC116 inhibits Aurora kinases A/B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.

Product Specification

Alternative Name:4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
 
Formula:C18H20N6OS
 
MW:368.5
 
CAS:693228-63-6
 
Purity:≥95% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:Brown powder.
 
Solubility:Soluble in DMSO (24mg/ml) or ethanol (1mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Aurora kinases are known to play a role in mitotic entry, progression and exit. These kinases represent attractive targets for anticancer drug development because they regulate both genomic integrity and cell cycle progression in cancer.
 
ENZ-CHM171 structure
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ENZ-CHM171 structure

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For Research Use Only. Not for use in diagnostic procedures.
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