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PD173955

Dual Src/Abl kinase inhibitor
 
ENZ-CHM170-0001 1 mg 168.00 USD
 
ENZ-CHM170-0005 5 mg 294.00 USD
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PD173955 is an ATP-competitive, dual Src/Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC50 of 1-2 nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC50 of 22 nM and could represent a novel class of anti-mitotic drug.

Product Specification

Alternative Name:6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one
 
Formula:C21H16Cl2N4OS
 
MW:443.4
 
CAS:260415-63-2
 
Purity:≥98% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:White powder.
 
Solubility:Soluble in DMSO (112mg/ml) or ethanol (4mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
ENZ-CHM170 structure
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ENZ-CHM170 structure

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Src kinase
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Src kinase Inhibitor
Abl Inhibitor
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