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(R)-BI-2536

Potent and selective inhibitor of mammalian Plk1
 
ENZ-CHM160-0005 5 mg 114.00 USD
 
ENZ-CHM160-0010 10 mg 158.00 USD
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Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple tumor lines with IC50 values below 1 µM. BI-2536 also shows an >1,000-fold selectivity for PIK1 versus a large panel of other kinases. BI-2536 also demonstrated low Kd values against sister kinases Plk2 and Plk3. Preclinical studies in human cancer cell lines have shown that BI 2536 disrupts spindle assembly, resulting in mitotic arrest and inducing apoptosis. BI-2536 is currently in clinical trials against several types of solid tumor cancers.

Product Specification

Formula:C28H39N7O3
 
MW:521.7
 
CAS:755038-02-9
 
Purity:≥97% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO (21mg/ml) or ethanol (100mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
ENZ-CHM160 structure
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