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Afatinib

ErbB-1, -2 and -4 tyrosine kinase inhibitor
 
ENZ-CHM158-0005 5 mg 97.00 USD
 
ENZ-CHM158-0010 10 mg 179.00 USD
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Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC50 values ranging from approximately 6nM to below 500 nM.

Product Specification

Alternative Name:Tovok, BIBW-2992
 
Formula:C24H25ClFN5O3
 
MW:485.9
 
CAS:850140-72-6
 
Purity:≥95% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO (97 mg/ml) or ethanol (15 mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
ENZ-CHM158 structure
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ENZ-CHM158 structure

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