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Nilotinib

Bcr-Abl tyrosine kinase inhibitor
 
ENZ-CHM149-0050 50 mg 165.00 USD
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Nilotinib is an orally bio-available aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor (IC50 < 30 nM) with anti-neoplastic activity.

Product Specification

Alternative Name:AMN107, Nilotinibum, 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
 
Formula:C28H22F3N7O
 
MW:529.5
 
CAS:641571-10-0
 
Purity:≥99% (HPLC)
 
Identity:Determined by EM-MS, NMR
 
Appearance:Beige powder.
 
Solubility:Soluble in DMSO (12 mg/ml) or ethanol (1mg/ml).
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:BCR-ABL, a common molecular defect in adult acute lymphoblastic leukemia, is a valuable tumor marker whose detection influences prognosis and clinical management decisions.
 
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ENZ-CHM149 structure

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