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AdipoRon

Novel and orally active adiponectin receptor agonist for AdipoR1 and AdipoR2.
 
ENZ-CHM101-0005 5 mg 68.00 USD
 
ENZ-CHM101-0010 10 mg 110.00 USD
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AdipoR agonist that binds to both AdipoR1 and AdipoR2.

Product Specification

Alternative Name:2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
 
Formula:C27H28N2O3
 
MW:428.52
 
CAS:924416-43-3
 
Purity:≥98% (HPLC)
 
Solubility:Soluble in DMSO (86mg/ml) or ethanol (50mg/ml). Slightly soluble in water (<1mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, up to 3 years at -20°C.
 
Scientific Background:Produced by adipocytes, adiponectin has circulating levels that are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index, while correlating positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin controls many metabolic processes and is known to contribute to metabolic pathologies including diabetes, atherosclerosis, and obesity. It has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Adiponectin receptor activation is a promising potential therapy for diabetes and other obesity-associated diseases. 

AdipoRon is a small-molecule adiponectin mimetic. At low micromolar concentrations, it binds to the adiponectin receptors AdipoR1 and AdipoR2. In addition, AdipoRon is orally administered and readily absorbed and delivered to target tissues, making it potentially clinically relevant. AdipoRon has been shown to induce insulin sensitivity, inhibit lipid synthesis and increase glucose metabolism.
 
ENZ-CHM101 structure
ENZ-CHM101 flowchart
Fig 1. AdipoRon and Adiponectin have similar downstream effects.
ENZ-42854 spectra
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ENZ-CHM101 structure ENZ-CHM101 flowchart ENZ-42854 spectra

Product Literature References

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity: M. Okada-Iwabu, et al.; Nature 503, 493 (2013), Abstract;
Cell Biology. Ronning after the adiponectin receptors: W.L. Holland, et. al.; Science 342, 1460 (2013), Abstract;

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