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Melanoma marker (human) monoclonal antibody (HMB45)

 
ENZ-C34930 0.5 ml ~10 µg 226.00 USD
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Alternative size available: ENZ-30930 (6ml)

Product Specification

Clone:HMB45
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Human axillary lymph node tissue containing pigmnted melanoma metastases.
 
Species reactivity:Human
 
Specificity:Recognizes a human melanoma-specific antigen present in melanocytic cells and junctional nevi. Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors.
 
Crossreactivity:Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors.
 
Applications:IHC (PS)
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections; this antibody can be used for staining of paraffin-embedded tissue sections fixed in neutral buffered formalin and is compatible with most commonly used histological fixatives. Choose a good quality enzyme-linked anti-mouse IgG1 antibody for detection). A 20- to 50-fold dilution of the antibody is suggested. Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually.
 
Purity Detail:Affinity purified.
 
Formulation:Liquid. In PBS containing 0.1% sodium azide and 1% BSA.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Unusual manifestations of secondary urothelial carcinoma: C.L. Zhao, et al.; Human Pathology: Case Reports 3, 1 (2016), Application(s): Immunohistochemical antibodies used for diagnosis of cases,
Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma: S. Yamada, et al.; World J. Gastroenterol. 21, 1349 (2015), Application(s): Immunohistochemistry, Abstract; Full Text
Sclerosing Epithelioid Fibrosarcoma of the Kidney: Clinicopathologic and Molecular Study of a Rare Neoplasm at a Novel Location: C.H. Ohlmann, et al.; Ann. Diagn. Pathol. 19, 221 (2015), Application(s): Immunohistochemistry, Abstract;
Comparison of HMB-45 monoclonal antibody and S-100 protein in the immunohistochemical diagnosis of melanoma: N.G. Ordonez, et al.; Am. J. Clin. Pathol. 90, 385 (1988), Abstract;
Immunohistochemical diagnosis of sinonasal melanoma, carcinoma, and neuroblastoma with monoclonal antibodies HMB-45 and anti-synaptophysin: M.R. Wick, et al.; Arch. Pathol. Lab. Med. 112, 616 (1988), Abstract;
Melanoma cell heterogeneity. A study of two monoclonal antibodies compared with S-100 protein in paraffin sections: P.H. Duray, et al.; Cancer 61, 2460 (1988), Abstract;
Recognition of malignant melanoma by monoclonal antibody HMB-45. An immunohistochemical study of 200 paraffin-embedded cutaneous tumors: M.R. Wick, et al.; J. Cutan. Pathol. 15, 201 (1988), Abstract;
Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes: A.M. Gown, et al.; Am. J. Pathol. 123, 195 (1986), Abstract; Full Text

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