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ATRX monoclonal antibody (39f)

 
ENZ-ABS773-0100 100 µg 595.00 USD
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Product Specification

Alternative Name:Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked nuclear protein, XNP
 
Clone:39f
 
Host:Mouse
 
Isotype:IgG1κ
 
Immunogen:Recombinant human ATRX protein.
 
UniProt ID:P46100
 
Species reactivity:Human
 
Applications:IHC, WB
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, it contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, it predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 α to mediate chromosomal segregation. Mutations in the gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha-thalassemia or ATRX syndrome.
 
ATRX monoclonal antibody (39f) IHC
IHC testing of FFPE human Rhabdomyosarcoma with recombinant MyoD1 antibody. Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH9, for 10-20 min followed by cooling at RT for 20 min.
ATRX monoclonal antibody (39f) SDS-PAGE
SDS-PAGE analysis of purified, recombinant MyoD1 antibody as confirmation of integrity and purity.
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ATRX monoclonal antibody (39f) IHC ATRX monoclonal antibody (39f) SDS-PAGE

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