| Alternative Name: | Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4 |
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| Clone: | SPM335 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Human androgen receptor, amino acids 302-318 (STEDTAEYSPFKGGYTK). |
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| UniProt ID: | P10275 |
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| Species reactivity: | Human
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| Specificity: | Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. |
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| Crossreactivity: | Does not cross react with estrogen, progesterone, or glucocorticoid receptors. |
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| Applications: | IHC
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| Application Notes: | This mAb is superb for staining of formalin/paraffin tissues. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. |
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| Regulatory Status: | RUO - Research Use Only |
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