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Transglutaminase 2 monoclonal antibody (419)

 
ENZ-ABS764-0100 100 µg 590.00 USD
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Product Specification

Alternative Name:Tissue transglutaminase, TGase 2, Protein-glutamine γ-glutamyltransferase
 
Clone:419
 
Host:Mouse
 
Isotype:IgG2aκ
 
Immunogen:Recombinant full-length human protein was used as the immunogen for the Transglutaminase 2 antibody.
 
UniProt ID:P21980
 
Species reactivity:Human
 
Specificity:Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II).
 
Applications:IHC
 
Purity Detail:Protein G affinity purified
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
 
Transglutaminase 2 monoclonal antibody (419) IHC tonsil
IHC Formalin-fixed, paraffin-embedded human tonsil stained with Transglutaminase 2 antibody 
Transglutaminase 2 monoclonal antibody (419) IHC placenta
IHC Formalin-fixed, paraffin-embedded human placenta stained with Transglutaminase 2 antibody.
Transglutaminase 2 monoclonal antibody (419) SDS-PAGE
SDS-PAGE Analysis of Purified Transglutaminase 2 Antibody
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Transglutaminase 2 monoclonal antibody (419) IHC tonsil Transglutaminase 2 monoclonal antibody (419) IHC placenta Transglutaminase 2 monoclonal antibody (419) SDS-PAGE

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