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Bax (active monomer) Recombinant monoclonal antibody (6A7)

 
ENZ-ABS754-0200 200 µg 635.00 USD
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Product Specification

Alternative Name:BCL2L4, BCL2-associated X protein
 
Clone:6A7
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to aa 12-24 of human Bax.
 
UniProt ID:Q07812
 
Species reactivity:Human, Mouse, Rat
 
Specificity:Recognizes the active monomeric form of Bax.
 
Crossreactivity:In the presence of nonionic detergent, the antibody binds the monomeric form of Bax, but not Bax complexed with either Bcl-XL or Bcl-2. Only recognizes conformationally changed active Bax.
 
Applications:IHC, IP, WB
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS with 0.02% Proclin 300.
 
Handling:After opening aliquot contents and freeze at -20°C. Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Bax and Bak operate in both the endoplasmatic reticulum (ER) and mitochondria as an essential gateway for selected apoptotic signals. A role for Bcl-2 at the ER has been suggested earlier as Bcl-2 may regulate calcium fluxes between the ER and the mitochondria. For a review on Ca2+ and its role in apoptosis.
 
ENZ-ABS754 IHC
IHC staining of human lung cancer using anti-Bax antibody. Formalin fixed human lung cancer slices were were stained with the antibody at 3 µg/ml.
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ENZ-ABS754 IHC

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