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CD86 polyclonal antibody

ENZ-ABS705-0100 100 µg 380.00 USD
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Product Specification

Alternative Name:LAB72, CD28LG2
Immunogen:Peptide corresponding to 17 amino acids near the center of human CD86. The immunogen is located within amino acids 160 - 210 of CD86.
UniProt ID:P42082
Species reactivity:Human
Applications:IF, IHC, WB
Purity Detail:Affinity chromatography purified via peptide column.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response. Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia, suggesting that this pathway may be an attractive target for future cancer immunotherapy.
CD86 polyclonal antibody WB
Western blot analysis of CD86 in (A) Daudi and (B) Raji cell lysate with CD86 antibody at 1 µg/mL.
CD86 polyclonal antibody IHC
Immunohistochemistry of CD86 in human lymph node tissue with CD86 antibody at 2 µg/ml.
CD86 polyclonal antibody IF
Immunofluorescence of CD86 in human lymph node tissue with CD86 antibody at 20 µg/ml. Red: CD86 Antibody (8681), Blue: DAPI staining.
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CD86 polyclonal antibody WB CD86 polyclonal antibody IHC CD86 polyclonal antibody IF

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