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CD86 polyclonal antibody

 
ENZ-ABS705-0100 100 µg 380.00 USD
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Product Specification

Alternative Name:LAB72, CD28LG2
 
Host:Rabbit
 
Isotype:IgG
 
Immunogen:Peptide corresponding to 17 amino acids near the center of human CD86. The immunogen is located within amino acids 160 - 210 of CD86.
 
UniProt ID:P42082
 
Species reactivity:Human
 
Applications:IF, IHC, WB
 
Purity Detail:Affinity chromatography purified via peptide column.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response. Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia, suggesting that this pathway may be an attractive target for future cancer immunotherapy.
 

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