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TIGIT monoclonal antibody (4A12)

 
ENZ-ABS698-0100 100 µg 457.00 USD
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Product Specification

Alternative Name:T-cell immunoreceptor with Ig and ITIM domains
 
Clone:4A12
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Extracellular domain of human TIGIT.
 
UniProt ID:Q495A1
 
Species reactivity:Human
 
Applications:Flow Cytometry, ICC, IF, IHC (PS), WB
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer.
 
TIGIT monoclonal antibody (4A12) IHC
Immunohistochemistry of TIGIT in human stomach carcinoma tissue using TIGIT Antibody and control mouse IgG (corner box) at 2 µg/ml.
TIGIT monoclonal antibody (4A12) WB
Western blot analysis of TIGIT in over expressing HEK293 cells using ENZ-ABS698 antibody at (A) 0.25 µg/ml , (B) 0.5 ug/ml, and (C) 1 µg/ml.
TIGIT monoclonal antibody (4A12) IF
Immunofluorescence of TIGIT in over expressing HEK293 cells using TIGIT Antibody at 1 µg/ml.
Green: TIGIT Antibody [4A12]
Blue: DAPI staining
TIGIT monoclonal antibody (4A12) ICC
Immunocytochemistry of TIGIT in over expressing HEK293 cells using TIGIT antibody and control mouse IgG antibody (left corner box) at 1 µg/ml.
TIGIT monoclonal antibody (4A12) FACS
Flow cytometry analysis of TIGIT over expressing HEK293 cells using TIGIT antibody at 1 µg/ml. Blue: untransfected HEK293 cells. Yellow: TIGIT over expressing HEK293 cells.
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TIGIT monoclonal antibody (4A12) IHC TIGIT monoclonal antibody (4A12) WB TIGIT monoclonal antibody (4A12) IF TIGIT monoclonal antibody (4A12) ICC TIGIT monoclonal antibody (4A12) FACS

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