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PD-L1 monoclonal antibody

Monoclonal antibody to PD-L1 for use with IHC applications
 
ENZ-ABS693-0100 100 µl 195.00 USD
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Product Specification

Alternative Name:Programmed cell death 1 ligand 1, CD274, B7-H1
 
Host:Mouse
 
Isotype:IgG
 
Immunogen:Recombinant PD-L1.
 
UniProt ID:Q9NZQ7
 
Species reactivity:Human
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:50-1:100)
Optimal conditions must be determined individually for each application.
 
Application Notes:For IHC applications: Dilute the concentrate as appropriate in antibody diluent, and then apply 150 µL to the slide, as indicated in the user's IHC protocol.
 
Purity Detail:Affinity-purified.
 
Formulation:Liquid. In Tris buffer, pH 7.5, containing 1% BSA and <0.1% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:+4°C
 
Scientific Background:PD-L1, also known as B7-H1 and CD274, is a 290 amino acid transmembrane glycoprotein in the B7 family of immune regulatory molecules. It has an extracellular domain that can interact with PD-1, which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. The PD1/PD-L1 interaction ensures that activation of the immune system occurs at the appropriate time. This will minimize the possibility of chronic autoimmune inflammation. PD-L1 is known to inhibit proliferation of T cells via apoptosis. It also plays an important role in arresting cell-cycle progression. This makes PD-L1 an attractive therapeutic target for cancer and immunologic diseases.
 
PD-L1 monoclonal antibody Immunohistochemistry
IHC using anti-PD-L1 (Prod. No. ENZ-ABS693) on lung adenocarcinoma tissue.
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PD-L1 monoclonal antibody Immunohistochemistry

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