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Globo H (human) monoclonal antibody (VK9)

ENZ-ABS379-0050 50 µg 299.00 USD

Product Specification

Immunogen:Globo H-KLH (keyhole limpet hemocyanin) synthetic conjugate
Species reactivity:Human
Applications:Flow Cytometry, IHC (PS), WB, Fluorescence microscopy
Recommended Dilutions/Conditions:Western Blot (5 µg/mL)
Immunohistochemistry (paraffin sections, 5 µg/mL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Affinity chromatography purified.
Formulation:Liquid. 0.2 µM filtered solution in PBS, pH 7.2, containing 0.09% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Globo H is a hexasaccharide formed from the pentasaccharide precursor, SSEA3 (stage-specific embryonic antigen 3). It is a member of a family of antigenic carbohydrates expressed on the surface of cancer cells as glycolipids and possibly glycoproteins. Globo H is overexpressed on many carcinomas, such as breast, colon, ovarian, gastric, pancreatic, lung, and prostate. Expression of Globo H in carcinomas include more than half of all ductal, lobular, and tubular breast carcinomas, but not in non-epithelial breast tumors. Cancer stem cells and human embryonic stem cells also express global H, although expression decreases when cells are differentiated toward both neural progenitor cells and to a lesser extent in endodermal lineage cells. Expression in normal tissues is limited to cells composing secretory borders. Globo H is considered a target for immunotherapy of many epithelial cancers.

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