| ENZ-ABS379-0050 | 50 µg | 388.00 USD |  |
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| Clone: | VK9 |
| Host: | Mouse |
| Isotype: | IgG3κ |
| Immunogen: | Globo H-KLH (keyhole limpet hemocyanin) synthetic conjugate |
| Species reactivity: | Human |
| Applications: | Flow Cytometry, IHC (PS), WB, Fluorescence microscopy |
| Recommended Dilutions/Conditions: | Western Blot (5 µg/mL) Immunohistochemistry (paraffin sections, 5 µg/mL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Affinity chromatography purified. |
| Formulation: | Liquid. 0.2 µM filtered solution in PBS, pH 7.2, containing 0.09% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | Globo H is a hexasaccharide formed from the pentasaccharide precursor, SSEA3 (stage-specific embryonic antigen 3). It is a member of a family of antigenic carbohydrates expressed on the surface of cancer cells as glycolipids and possibly glycoproteins. Globo H is overexpressed on many carcinomas, such as breast, colon, ovarian, gastric, pancreatic, lung, and prostate. Expression of Globo H in carcinomas include more than half of all ductal, lobular, and tubular breast carcinomas, but not in non-epithelial breast tumors. Cancer stem cells and human embryonic stem cells also express global H, although expression decreases when cells are differentiated toward both neural progenitor cells and to a lesser extent in endodermal lineage cells. Expression in normal tissues is limited to cells composing secretory borders. Globo H is considered a target for immunotherapy of many epithelial cancers. |
| Regulatory Status: | RUO - Research Use Only |
