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p53 Recombinant monoclonal antibody (TP53/1799R)

 
ENZ-ABS374-0100 100 µg 440.00 USD
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Product Specification

Alternative Name:TRP53, Tumor protein p53
 
Clone:TP53/1799R
 
Host:Rabbit
 
Isotype:IgGκ
 
Immunogen:Recombinant human p53.
 
UniProt ID:P04637
 
Species reactivity:Human
 
Specificity:Recognizes the mutant as well as the wild form of p53.
 
Applications:Flow Cytometry, IF, IHC (PS), WB
 
Recommended Dilutions/Conditions:Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 µg/mL)
Immunohistochemistry (formalin-fixed paraffin sections) (0.25-0.5 µg/mL for 30 minutes at RT)
Western blot (0.5-1 µg/mL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
 

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