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NKX2.2 Recombinant monoclonal antibody (NX2/1422R)

 
ENZ-ABS370-0100 100 µg 440.00 USD
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Product Specification

Alternative Name:Homeobox protein Nkx-2.2
 
Clone:NX2/1422R
 
Host:Rabbit
 
Isotype:IgGκ
 
Immunogen:Recombinant human NKX2.2 protein fragment.
 
UniProt ID:O95096
 
Gene/Protein Identifier:4821 (Gene ID)
 
Species reactivity:Human
 
Applications:Flow Cytometry, IF, IHC (PS)
 
Recommended Dilutions/Conditions:Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL)
Immunofluorescence (1-2 µg/mL)
Immunohistochemistry (formalin-fixed paraffin sections) (1-2 µg/mL for 30 minutes at RT)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:NKX2.2 acts as a transcriptional activator. Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis.
 

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