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Acidic Cytokeratin Recombinant monoclonal antibody (RMAK1-1)

ENZ-ABS335-0100 100 µg 440.00 USD
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Product Specification

Immunogen:An amino acid sequence common to acidic/type I keratins.
UniProt ID:Q7Z794
Species reactivity:Human
Applications:IF, IHC (PS)
Recommended Dilutions/Conditions:Immunofluorescence (0.5-1 µg/mL)
Immunohistochemistry (formalin-fixed paraffin sections) (0.5-1 µg/mL for 30 min at RT)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:+4°C
Scientific Background:There are two types of cytokeratins/keratins/CKs: the acidic type I cytokeratins and the basic or neutral type II cytokeratins. The subsets of cytokeratins which an epithelial cell expresses depends mainly on the type of epithelium, the moment in the course of terminal differentiation and the stage of development. Thus this specific keratin fingerprint allows the classification of all epithelia upon their keratin expression profile. Furthermore this applies also to the malignant counterparts of the epithelia (carcinomas), as the keratin profile tends to remain constant when an epithelium undergoes malignant transformation. The main clinical implication is that the study of the keratin profile by immunohistochemistry techniques is a tool of immense value widely used for tumor diagnosis and characterization in surgical pathology. [Wiki]

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