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CD30 Recombinant monoclonal antibody (rKi-1/779)

 
ENZ-ABS327-0100 100 µg 385.00 USD
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Product Specification

Alternative Name:Ki-1, TNFRSF 8
 
Clone:rKi-1/779
 
Host:Mouse
 
Isotype:lgG1κ
 
Immunogen:Recombinant full length human CD30.
 
UniProt ID:P28908
 
Species reactivity:Human
 
Applications:Flow Cytometry, IF, IHC (PS)
 
Recommended Dilutions/Conditions:Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL)
Immunofluorescence (1-2 µg/mL)
Immunohistochemistry (formalin-fixed paraffin sections) (0.5-1 µg/mL for 30 min at RT)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:This mAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. About one third of the CD30/Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
 

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