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DOG1 Recombinant monoclonal antibody (DG1/1487R)

 
ENZ-ABS325-0100 100 µg 440.00 USD
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Product Specification

Alternative Name:Discovered on gastrointestinal stromal tumors protein 1, ANO1, Anoctamin-1, TMEM16A, Transmembrane protein 16A
 
Clone:DG1/1487R
 
Host:Rabbit
 
Isotype:IgGκ
 
Immunogen:Recombinant full length human DOG1.
 
UniProt ID:Q5XXA6
 
Gene/Protein Identifier:55107 (Gene ID)
 
Species reactivity:Human
 
Applications:Flow Cytometry, IF, IHC (PS)
 
Recommended Dilutions/Conditions:Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 µg/mL)
Immunohistochemistry (formalin-fixed paraffin sections) (0.25-0.5 µg/mL) for 30 minutes at RT
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 % of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including platelet-derived growth factor Receptor α mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
 

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